11β-(3,4-difluorophenyl)-3,3-[1,2-ethanediylbis(oxy)]-5α-hydroxy-17-(N-hydroxyimino)estr-9-ene

Base Information

Chemical Name:11β-(3,4-difluorophenyl)-3,3-[1,2-ethanediylbis(oxy)]-5α-hydroxy-17-(N-hydroxyimino)estr-9-ene
CAS No.:940932-53-6
Molecular Formula:C₂₆H₃₁F₂NO₄
Molecular Weight:459.533
Hs Code.:

Synonyms:11β-(3,4-difluorophenyl)-3,3-[1,2-ethanediylbis(oxy)]-5α-hydroxy-17-(N-hydroxyimino)estr-9-ene

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Chemical Property of 11β-(3,4-difluorophenyl)-3,3-[1,2-ethanediylbis(oxy)]-5α-hydroxy-17-(N-hydroxyimino)estr-9-ene

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Technology Process of 11β-(3,4-difluorophenyl)-3,3-[1,2-ethanediylbis(oxy)]-5α-hydroxy-17-(N-hydroxyimino)estr-9-ene

There total 3 articles about 11β-(3,4-difluorophenyl)-3,3-[1,2-ethanediylbis(oxy)]-5α-hydroxy-17-(N-hydroxyimino)estr-9-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 940932-52-5
11β-(3,4-difluorophenyl)-3,3-[1,2-ethanediylbis(oxy)]-5α-hydroxyestr-9-en-17-one

: 940932-53-6
11β-(3,4-difluorophenyl)-3,3-[1,2-ethanediylbis(oxy)]-5α-hydroxy-17-(N-hydroxyimino)estr-9-ene

Guidance literature:: With pyridine; 4 A molecular sieve; hydroxylamine hydrochloride; at 20 ℃; for 10h;
DOI:10.1021/ol070447d

Reference yield:

: 39931-88-9,116003-08-8,39931-87-8
(5'R,10'R,13'S)-13'-methyl-1',2',6',7',8',12',13',14',15',16'-decahydro-17'H-spiro[1,3-dioxolane-2,3'-[5,10]epoxycyclopenta[a]phenanthren]-17'-one

: 940932-53-6
11β-(3,4-difluorophenyl)-3,3-[1,2-ethanediylbis(oxy)]-5α-hydroxy-17-(N-hydroxyimino)estr-9-ene

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / CuI / tetrahydrofuran / 0.5 h / 0 °C

2: pyridine; hydroxylamine hydrochloride; 4 Angstroem molecular sieves / 10 h / 20 °C

With pyridine; copper(l) iodide; 4 A molecular sieve; hydroxylamine hydrochloride; In tetrahydrofuran;
DOI:10.1021/ol070447d

Reference yield:

: 5571-36-8
ethylene deltenone

: 940932-53-6
11β-(3,4-difluorophenyl)-3,3-[1,2-ethanediylbis(oxy)]-5α-hydroxy-17-(N-hydroxyimino)estr-9-ene

Guidance literature:: Multi-step reaction with 3 steps

1: 53 percent / hexafluoroacetone trihydrate; Na₂HPO₄; aq. H₂O₂ / CH₂Cl₂ / 18 h / 0 - 20 °C

2: 92 percent / CuI / tetrahydrofuran / 0.5 h / 0 °C

3: pyridine; hydroxylamine hydrochloride; 4 Angstroem molecular sieves / 10 h / 20 °C

With pyridine; disodium hydrogenphosphate; copper(l) iodide; 4 A molecular sieve; hydroxylamine hydrochloride; dihydrogen peroxide; Hexafluoroacetone; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol070447d