3-nitro-5-cyano-benzoylchloride

Base Information

• Chemical Name: 3-nitro-5-cyano-benzoylchloride
• CAS No.: 1407751-67-0
• Molecular Formula: C₈H₃ClN₂O₃
• Molecular Weight: 210.576
• Mol file: 1407751-67-0.mol

Synonyms:3-nitro-5-cyano-benzoylchloride

Chemical Property of 3-nitro-5-cyano-benzoylchloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-nitro-5-cyano-benzoylchloride

There total 2 articles about 3-nitro-5-cyano-benzoylchloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-cyano-5-nitrobenzoic acid (98556-65-1) → 3-nitro-5-cyano-benzoylchloride (1407751-67-0)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 4h; Reflux;

Reference yield:

3-amino-5-nitro-benzoic acid (618-84-8) → 3-nitro-5-cyano-benzoylchloride (1407751-67-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride; sodium nitrite / water / 0 - 5 °C

1.2: 0 - 5 °C / pH 6 - 7

1.3: 0.67 h / 65 °C / Reflux

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 4 h / 20 °C / Reflux

With hydrogenchloride; oxalyl dichloride; sodium nitrite; N,N-dimethyl-formamide; In dichloromethane; water;

Reference yield:

4-heptafluoroisopropyl-2,6-dimethylaniline (273735-43-6) + 3-nitro-5-cyano-benzoylchloride (1407751-67-0) → 3-cyano-N-[2,6-dimethyl-4-(1,2,2,2-tetrafluoro-1-trifluoromethyl-ethyl)-phenyl]-5-nitro-benzamide (1033997-02-2)

Guidance literature:

With pyridine; In tetrahydrofuran; at 0 - 20 ℃; for 12h;

upstream raw materials:

3-cyano-5-nitrobenzoic acid

3-amino-5-nitro-benzoic acid

Downstream raw materials:

3-cyano-N-[2,6-dimethyl-4-(1,2,2,2-tetrafluoro-1-trifluoromethyl-ethyl)-phenyl]-5-nitro-benzamide

Refernces