ethyl 5-[1-(2-nitrobenzenesulfonyl)indol-3-yl]-2-pentyloxazole-4-carboxylate

Base Information

Chemical Name:ethyl 5-[1-(2-nitrobenzenesulfonyl)indol-3-yl]-2-pentyloxazole-4-carboxylate
CAS No.:1026462-02-1
Molecular Formula:C₂₅H₂₅N₃O₇S
Molecular Weight:511.555
Hs Code.:

Synonyms:ethyl 5-[1-(2-nitrobenzenesulfonyl)indol-3-yl]-2-pentyloxazole-4-carboxylate

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Chemical Property of ethyl 5-[1-(2-nitrobenzenesulfonyl)indol-3-yl]-2-pentyloxazole-4-carboxylate

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Technology Process of ethyl 5-[1-(2-nitrobenzenesulfonyl)indol-3-yl]-2-pentyloxazole-4-carboxylate

There total 6 articles about ethyl 5-[1-(2-nitrobenzenesulfonyl)indol-3-yl]-2-pentyloxazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 862538-74-7
ethyl 2-hexanoylamino-3-[1-(2-nitrobenzenesulfonyl)indol-3-yl]-3-oxopropanoate

: 1026462-02-1
ethyl 5-[1-(2-nitrobenzenesulfonyl)indol-3-yl]-2-pentyloxazole-4-carboxylate

Guidance literature:: With iodine; triethylamine; triphenylphosphine; In dichloromethane; for 16h;
DOI:10.1021/jo050303h

Reference yield:

: 862538-66-7
ethyl 2-diazo-3-[1-(2-nitrobenzenesulfonyl)indol-3-yl]-3-oxopropanoate

: 1026462-02-1
ethyl 5-[1-(2-nitrobenzenesulfonyl)indol-3-yl]-2-pentyloxazole-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 52 percent / dirhodium(II) tetraoctanoate / CH₂Cl₂ / Heating

2: 85 percent / triphenylphosphine; iodine; triethylamine / CH₂Cl₂ / 16 h

With iodine; triethylamine; triphenylphosphine; rhodium (II) octanoate dimer; In dichloromethane; 2: Robinson-Gabriel cyclodehydration;
DOI:10.1021/jo050303h

Reference yield:

: 2-diazo-3-hydroxy-3-[1-(2-nitro-benzenesulfonyl)-1H-indol-3-yl]-propionic acid ethyl ester

: 1026462-02-1
ethyl 5-[1-(2-nitrobenzenesulfonyl)indol-3-yl]-2-pentyloxazole-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 223 mg / iodoxybenzoic acid / dimethylsulfoxide / 3 h

2: 52 percent / dirhodium(II) tetraoctanoate / CH₂Cl₂ / Heating

3: 85 percent / triphenylphosphine; iodine; triethylamine / CH₂Cl₂ / 16 h

With iodine; triethylamine; triphenylphosphine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; rhodium (II) octanoate dimer; In dichloromethane; dimethyl sulfoxide; 3: Robinson-Gabriel cyclodehydration;
DOI:10.1021/jo050303h