ethyl 2-hexanoylamino-3-[1-(2-nitrobenzenesulfonyl)indol-3-yl]-3-oxopropanoate

Base Information

Chemical Name:ethyl 2-hexanoylamino-3-[1-(2-nitrobenzenesulfonyl)indol-3-yl]-3-oxopropanoate
CAS No.:862538-74-7
Molecular Formula:C₂₅H₂₇N₃O₈S
Molecular Weight:529.571
Hs Code.:

Synonyms:ethyl 2-hexanoylamino-3-[1-(2-nitrobenzenesulfonyl)indol-3-yl]-3-oxopropanoate

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Chemical Property of ethyl 2-hexanoylamino-3-[1-(2-nitrobenzenesulfonyl)indol-3-yl]-3-oxopropanoate

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Technology Process of ethyl 2-hexanoylamino-3-[1-(2-nitrobenzenesulfonyl)indol-3-yl]-3-oxopropanoate

There total 5 articles about ethyl 2-hexanoylamino-3-[1-(2-nitrobenzenesulfonyl)indol-3-yl]-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 862538-66-7
ethyl 2-diazo-3-[1-(2-nitrobenzenesulfonyl)indol-3-yl]-3-oxopropanoate

: 628-02-4
Caproamide

: 862538-74-7
ethyl 2-hexanoylamino-3-[1-(2-nitrobenzenesulfonyl)indol-3-yl]-3-oxopropanoate

Guidance literature:: rhodium (II) octanoate dimer; In dichloromethane; Heating;
DOI:10.1021/jo050303h

Reference yield:

: 2-diazo-3-hydroxy-3-[1-(2-nitro-benzenesulfonyl)-1H-indol-3-yl]-propionic acid ethyl ester

: 862538-74-7
ethyl 2-hexanoylamino-3-[1-(2-nitrobenzenesulfonyl)indol-3-yl]-3-oxopropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 223 mg / iodoxybenzoic acid / dimethylsulfoxide / 3 h

2: 52 percent / dirhodium(II) tetraoctanoate / CH₂Cl₂ / Heating

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; rhodium (II) octanoate dimer; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jo050303h

Reference yield:

: 487-89-8,1228547-52-1
Indole-3-carboxaldehyde

: 862538-74-7
ethyl 2-hexanoylamino-3-[1-(2-nitrobenzenesulfonyl)indol-3-yl]-3-oxopropanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 93 percent / sodium hydroxide; tetrabutylammonium hydrogen sulfate / CH₂Cl₂ / 2 h

2.1: diethylzinc / CH₂Cl₂; hexane / 0.5 h / cooling

2.2: CH₂Cl₂; hexane / cooling

3.1: 223 mg / iodoxybenzoic acid / dimethylsulfoxide / 3 h

4.1: 52 percent / dirhodium(II) tetraoctanoate / CH₂Cl₂ / Heating

With sodium hydroxide; diethylzinc; tetra(n-butyl)ammonium hydrogensulfate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; rhodium (II) octanoate dimer; In hexane; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jo050303h