1-[2-(N-ethoxycarbonyl-N-trifluoromethanesulphonyl)-aminobenzyl]piperidin-2-one

Base Information

Chemical Name:1-[2-(N-ethoxycarbonyl-N-trifluoromethanesulphonyl)-aminobenzyl]piperidin-2-one
CAS No.:1215109-26-4
Molecular Formula:C₁₆H₁₉F₃N₂O₅S
Molecular Weight:408.398
Hs Code.:

Synonyms:1-[2-(N-ethoxycarbonyl-N-trifluoromethanesulphonyl)-aminobenzyl]piperidin-2-one

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Chemical Property of 1-[2-(N-ethoxycarbonyl-N-trifluoromethanesulphonyl)-aminobenzyl]piperidin-2-one

Chemical Property:

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Technology Process of 1-[2-(N-ethoxycarbonyl-N-trifluoromethanesulphonyl)-aminobenzyl]piperidin-2-one

There total 2 articles about 1-[2-(N-ethoxycarbonyl-N-trifluoromethanesulphonyl)-aminobenzyl]piperidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1215109-18-4
1-(2-trifluoromethanesulfonylaminobenzyl)piperidin-2-one

: 541-41-3
chloroformic acid ethyl ester

: 1215109-26-4
1-[2-(N-ethoxycarbonyl-N-trifluoromethanesulphonyl)-aminobenzyl]piperidin-2-one

Guidance literature:: 1-(2-trifluoromethanesulfonylaminobenzyl)piperidin-2-one; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.0833333h; Cooling with ice;

chloroformic acid ethyl ester; In tetrahydrofuran; mineral oil; for 16h; Cooling with ice;

Reference yield:

: 147611-19-6
1,1,1-trifluoro-N-[2-(hydroxymethyl)phenyl]methanesulfonamide

: 1215109-26-4
1-[2-(N-ethoxycarbonyl-N-trifluoromethanesulphonyl)-aminobenzyl]piperidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid / toluene / 6 h / Reflux

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h / 20 °C / Cooling with ice

2.2: 16 h / Cooling with ice

With sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; toluene; mineral oil;

Reference yield:

: 1215109-26-4
1-[2-(N-ethoxycarbonyl-N-trifluoromethanesulphonyl)-aminobenzyl]piperidin-2-one

: 1-[2-(N-ethoxycarbonyl-N-trifluoromethanesulphonyl)amino-benzyl]-3-bromopiperidin-2-one

Guidance literature:: 1-[2-(N-ethoxycarbonyl-N-trifluoromethanesulphonyl)-aminobenzyl]piperidin-2-one; With trimethylsilyl trifluoromethanesulfonate; triethylamine; In dichloromethane; for 1h; Cooling with ice;

With phenyltrimethylammonium tribromide; In dichloromethane; at 20 ℃; Cooling with ice;