(3S,4S)-tert-butyl 3-(2-(tert-butoxycarbonyl(3-fluorophenethyl)amino)ethylamino)-4-((6-(tert-butoxycarbonylamino)-4-methylpyridin-2-yl)methyl)pyrrolidine-1-carboxylate

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Chemical Name:(3S,4S)-tert-butyl 3-(2-(tert-butoxycarbonyl(3-fluorophenethyl)amino)ethylamino)-4-((6-(tert-butoxycarbonylamino)-4-methylpyridin-2-yl)methyl)pyrrolidine-1-carboxylate
CAS No.:1018909-92-6
Molecular Formula:C₃₆H₅₄FN₅O₆
Molecular Weight:671.853
Hs Code.:

(3S,4S)-tert-butyl 3-(2-(tert-butoxycarbonyl(3-fluorophenethyl)amino)ethylamino)-4-((6-(tert-butoxycarbonylamino)-4-methylpyridin-2-yl)methyl)pyrrolidine-1-carboxylate

Synonyms:(3S,4S)-tert-butyl 3-(2-(tert-butoxycarbonyl(3-fluorophenethyl)amino)ethylamino)-4-((6-(tert-butoxycarbonylamino)-4-methylpyridin-2-yl)methyl)pyrrolidine-1-carboxylate

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Chemical Property of (3S,4S)-tert-butyl 3-(2-(tert-butoxycarbonyl(3-fluorophenethyl)amino)ethylamino)-4-((6-(tert-butoxycarbonylamino)-4-methylpyridin-2-yl)methyl)pyrrolidine-1-carboxylate

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Technology Process of (3S,4S)-tert-butyl 3-(2-(tert-butoxycarbonyl(3-fluorophenethyl)amino)ethylamino)-4-((6-(tert-butoxycarbonylamino)-4-methylpyridin-2-yl)methyl)pyrrolidine-1-carboxylate

There total 11 articles about (3S,4S)-tert-butyl 3-(2-(tert-butoxycarbonyl(3-fluorophenethyl)amino)ethylamino)-4-((6-(tert-butoxycarbonylamino)-4-methylpyridin-2-yl)methyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1018909-89-1
tert-butyl 3-fluorophenethyl(2'-oxoethyl)carbamate

: 1018909-91-5
(3S,4S)-tert-butyl 3-amino-4-((6-(tert-butoxycarbonylamino)-4-methylpyridin-2-yl)methyl)pyrrolidine-1-carboxylate

: 1018909-92-6
(3S,4S)-tert-butyl 3-(2-(tert-butoxycarbonyl(3-fluorophenethyl)amino)ethylamino)-4-((6-(tert-butoxycarbonylamino)-4-methylpyridin-2-yl)methyl)pyrrolidine-1-carboxylate

Guidance literature:: tert-butyl 3-fluorophenethyl(2'-oxoethyl)carbamate; (3S,4S)-tert-butyl 3-amino-4-((6-(tert-butoxycarbonylamino)-4-methylpyridin-2-yl)methyl)pyrrolidine-1-carboxylate; With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 0.5h; Molecular sieve; N₂ atmosphere;

With sodium tris(acetoxy)borohydride; at 20 ℃; for 16h; N₂ atmosphere;
DOI:10.1021/ja910228a

Reference yield:

: trans-[6-(1-benzyl-4-hydroxy-pyrrolidin-3-ylmethyl)-4-methyl-pyridin-2-yl]-carbamic acid tert-butyl ester

: 1018909-92-6
(3S,4S)-tert-butyl 3-(2-(tert-butoxycarbonyl(3-fluorophenethyl)amino)ethylamino)-4-((6-(tert-butoxycarbonylamino)-4-methylpyridin-2-yl)methyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 11 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 0 °C

1.2: 0 - 20 °C

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C

3.1: methanol; sodium hydroxide; water / 20 °C

3.2: pH 7

4.1: dmap; triethylamine / dichloromethane / 7 h / 0 - 20 °C

5.1: methanol; water

6.1: methanol; water; sodium carbonate / 14 h / 20 °C

7.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.33 h / 0 °C

7.2: 48 h / 0 - 20 °C

8.1: methanol; water; sodium carbonate / 14 h / 20 °C

9.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.33 h / 0 °C

9.2: 22 h / 0 - 20 °C

10.1: hydrogen / palladium(II) hydroxide/carbon / ethanol / 36 h / 60 °C

11.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 16.5 h / 20 °C / Molecular sieves 3 ?

With methanol; dmap; sodium hydroxide; di-isopropyl azodicarboxylate; water; hydrogen; sodium tris(acetoxy)borohydride; sodium hydride; sodium carbonate; triethylamine; triphenylphosphine; palladium(II) hydroxide/carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 1018909-90-4
(3S,4S)-tert-butyl 3-azido-4-{{6-[benzyl(tert-butoxycarbonyl)amino]-4-methylpyridin-2-yl}methyl}-4-hydroxypyrrolidine-1-carboxylate

: 1018909-92-6
(3S,4S)-tert-butyl 3-(2-(tert-butoxycarbonyl(3-fluorophenethyl)amino)ethylamino)-4-((6-(tert-butoxycarbonylamino)-4-methylpyridin-2-yl)methyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium(II) hydroxide/carbon / ethanol / 36 h / 60 °C

2: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 16.5 h / 20 °C / Molecular sieves 3 ?

With hydrogen; sodium tris(acetoxy)borohydride; palladium(II) hydroxide/carbon; In ethanol; 1,2-dichloro-ethane;