N,N-dimethyl-(2-triisopropylsilanylimidazole)-1-sulfonamide

Base Information

• Chemical Name: N,N-dimethyl-(2-triisopropylsilanylimidazole)-1-sulfonamide
• CAS No.: 936336-89-9
• Molecular Formula: C₁₄H₂₉N₃O₂SSi
• Molecular Weight: 331.555
• Mol file: 936336-89-9.mol

Synonyms:N,N-dimethyl-(2-triisopropylsilanylimidazole)-1-sulfonamide

Chemical Property of N,N-dimethyl-(2-triisopropylsilanylimidazole)-1-sulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N-dimethyl-(2-triisopropylsilanylimidazole)-1-sulfonamide

There total 1 articles about N,N-dimethyl-(2-triisopropylsilanylimidazole)-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

triisopropylsilyl trifluoromethanesulfonate (80522-42-5) + N,N-dimethyl-1H-imidazole-1-sulfonamide (78162-58-0) → N,N-dimethyl-(2-triisopropylsilanylimidazole)-1-sulfonamide (936336-89-9)

Guidance literature:

N,N-dimethyl-1H-imidazole-1-sulfonamide; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.666667h;

triisopropylsilyl trifluoromethanesulfonate; In tetrahydrofuran; hexane; at -78 - 20 ℃; Further stages.;

DOI:10.1021/jm0613469

Reference yield: 48.0%

N,N-dimethyl-(2-triisopropylsilanylimidazole)-1-sulfonamide (936336-89-9) + (3-iodomethylbenzyloxy)-triisopropylsilane (936336-92-4) → (N,N-dimethyl)-[2-triisopropylsilanyl-5-(3-triisopropylsilanyloxymethylbenzyl)-imidazole]-1-sulfonamide (936336-93-5)

Guidance literature:

N,N-dimethyl-(2-triisopropylsilanylimidazole)-1-sulfonamide; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

(3-iodomethylbenzyloxy)-triisopropylsilane; In tetrahydrofuran; hexane; at -78 - 20 ℃; Further stages.;

DOI:10.1021/jm0613469

Reference yield:

N,N-dimethyl-(2-triisopropylsilanylimidazole)-1-sulfonamide (936336-89-9) → (N,N-dimethyl)-[5-(3-hydroxymethylbenzyl)-imidazole]-1-sulfonamide (936336-94-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: 48 percent / tetrahydrofuran; hexane / -78 - 20 °C

2.1: 83 percent / tetrabutylammonium fluoride / tetrahydrofuran / 4 h / 20 - 40 °C

With n-butyllithium; tetrabutyl ammonium fluoride; In tetrahydrofuran; hexane;

DOI:10.1021/jm0613469

upstream raw materials:

triisopropylsilyl trifluoromethanesulfonate

N,N-dimethyl-1H-imidazole-1-sulfonamide

Downstream raw materials:

(N,N-dimethyl)-[2-triisopropylsilanyl-5-(3-triisopropylsilanyloxymethylbenzyl)-imidazole]-1-sulfonamide

(N,N-dimethyl)-[5-(3-hydroxymethylbenzyl)-imidazole]-1-sulfonamide

C₁₃H₁₅O₃N₃S

3-(dimethylsulfamoyl-3H-imidazol-4-ylmethyl)-benzoic acid