(N,N-dimethyl)-[2-triisopropylsilanyl-5-(3-triisopropylsilanyloxymethylbenzyl)-imidazole]-1-sulfonamide

Base Information

Chemical Name:(N,N-dimethyl)-[2-triisopropylsilanyl-5-(3-triisopropylsilanyloxymethylbenzyl)-imidazole]-1-sulfonamide
CAS No.:936336-93-5
Molecular Formula:C₃₁H₅₇N₃O₃SSi₂
Molecular Weight:608.049
Hs Code.:

Synonyms:(N,N-dimethyl)-[2-triisopropylsilanyl-5-(3-triisopropylsilanyloxymethylbenzyl)-imidazole]-1-sulfonamide

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Chemical Property of (N,N-dimethyl)-[2-triisopropylsilanyl-5-(3-triisopropylsilanyloxymethylbenzyl)-imidazole]-1-sulfonamide

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Technology Process of (N,N-dimethyl)-[2-triisopropylsilanyl-5-(3-triisopropylsilanyloxymethylbenzyl)-imidazole]-1-sulfonamide

There total 8 articles about (N,N-dimethyl)-[2-triisopropylsilanyl-5-(3-triisopropylsilanyloxymethylbenzyl)-imidazole]-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 936336-89-9
N,N-dimethyl-(2-triisopropylsilanylimidazole)-1-sulfonamide

: 936336-92-4
(3-iodomethylbenzyloxy)-triisopropylsilane

: 936336-93-5
(N,N-dimethyl)-[2-triisopropylsilanyl-5-(3-triisopropylsilanyloxymethylbenzyl)-imidazole]-1-sulfonamide

Guidance literature:: N,N-dimethyl-(2-triisopropylsilanylimidazole)-1-sulfonamide; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

(3-iodomethylbenzyloxy)-triisopropylsilane; In tetrahydrofuran; hexane; at -78 - 20 ℃; Further stages.;
DOI:10.1021/jm0613469

Reference yield:

: 1877-71-0
benzene 1,3-dicarboxylic acid monomethyl ester

: 936336-93-5
(N,N-dimethyl)-[2-triisopropylsilanyl-5-(3-triisopropylsilanyloxymethylbenzyl)-imidazole]-1-sulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 92 percent / BF₃*THF / tetrahydrofuran / 0.75 h / 20 °C

2.1: 93 percent / pyridine / DMAP; pyridine p-toluenesulfonate / CH₂Cl₂ / 1 h / 20 °C

3.1: 88 percent / LiAlH₄ / tetrahydrofuran / 2 h / Heating

4.1: 63 percent / mesyl chloride; NEt₃ / 20 °C

5.1: 92 percent / NaI / acetone / 72 h / 20 °C

6.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

6.2: 48 percent / tetrahydrofuran; hexane / -78 - 20 °C

With pyridine; lithium aluminium tetrahydride; n-butyllithium; boron trifluoride-tetrahydrofuran complex; methanesulfonyl chloride; triethylamine; sodium iodide; dmap; pyridinium p-toluenesulfonate; In tetrahydrofuran; hexane; dichloromethane; acetone;
DOI:10.1021/jm0613469

Reference yield:

: 67853-03-6
methyl 3-(hydroxymethyl)benzoate

: 936336-93-5
(N,N-dimethyl)-[2-triisopropylsilanyl-5-(3-triisopropylsilanyloxymethylbenzyl)-imidazole]-1-sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 93 percent / pyridine / DMAP; pyridine p-toluenesulfonate / CH₂Cl₂ / 1 h / 20 °C

2.1: 88 percent / LiAlH₄ / tetrahydrofuran / 2 h / Heating

3.1: 63 percent / mesyl chloride; NEt₃ / 20 °C

4.1: 92 percent / NaI / acetone / 72 h / 20 °C

5.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

5.2: 48 percent / tetrahydrofuran; hexane / -78 - 20 °C

With pyridine; lithium aluminium tetrahydride; n-butyllithium; methanesulfonyl chloride; triethylamine; sodium iodide; dmap; pyridinium p-toluenesulfonate; In tetrahydrofuran; hexane; dichloromethane; acetone;
DOI:10.1021/jm0613469