N,N'-bis(3-fluorophenyl)-N-(3-methylphenyl)-N'-{4-[3-(trityloxy)propoxy]phenyl}-1,1'-biphenyl-4,4'-diamine

Base Information

Chemical Name:N,N'-bis(3-fluorophenyl)-N-(3-methylphenyl)-N'-{4-[3-(trityloxy)propoxy]phenyl}-1,1'-biphenyl-4,4'-diamine
CAS No.:464216-88-4
Molecular Formula:C₅₉H₄₈F₂N₂O₂
Molecular Weight:855.039
Hs Code.:

Synonyms:N,N'-bis(3-fluorophenyl)-N-(3-methylphenyl)-N'-{4-[3-(trityloxy)propoxy]phenyl}-1,1'-biphenyl-4,4'-diamine

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Chemical Property of N,N'-bis(3-fluorophenyl)-N-(3-methylphenyl)-N'-{4-[3-(trityloxy)propoxy]phenyl}-1,1'-biphenyl-4,4'-diamine

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Technology Process of N,N'-bis(3-fluorophenyl)-N-(3-methylphenyl)-N'-{4-[3-(trityloxy)propoxy]phenyl}-1,1'-biphenyl-4,4'-diamine

There total 11 articles about N,N'-bis(3-fluorophenyl)-N-(3-methylphenyl)-N'-{4-[3-(trityloxy)propoxy]phenyl}-1,1'-biphenyl-4,4'-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 220716-54-1
N-(4'-bromo-1,1'-biphenyl-4-yl)-N-(3-fluorophenyl)-N-(3-methylphenyl)amine

: 3-fluoro-N-{4-[3-(trityloxy)propoxy]phenyl}aniline

: 464216-88-4
N,N'-bis(3-fluorophenyl)-N-(3-methylphenyl)-N'-{4-[3-(trityloxy)propoxy]phenyl}-1,1'-biphenyl-4,4'-diamine

Guidance literature:: N-(4'-bromo-1,1'-biphenyl-4-yl)-N-(3-fluorophenyl)-N-(3-methylphenyl)amine; 3-fluoro-N-{4-[3-(trityloxy)propoxy]phenyl}aniline; With 1,1'-bis-(diphenylphosphino)ferrocene; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In toluene; for 0.166667h;

With sodium t-butanolate; In toluene; at 90 ℃;
DOI:10.1055/s-2002-32533

Reference yield:

: 372-19-0
meta-fluoroaniline

: 464216-88-4
N,N'-bis(3-fluorophenyl)-N-(3-methylphenyl)-N'-{4-[3-(trityloxy)propoxy]phenyl}-1,1'-biphenyl-4,4'-diamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: DPPF / Pd₂(dba)3 / toluene / 0.17 h

1.2: 83 percent / t-BuONa / toluene / 90 °C

2.1: DPPF / Pd₂(dba)3 / toluene / 0.17 h

2.2: 92 percent / t-BuONa / toluene / 90 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In toluene;
DOI:10.1055/s-2002-32533

Reference yield:

: 106-41-2
4-bromo-phenol

: 464216-88-4
N,N'-bis(3-fluorophenyl)-N-(3-methylphenyl)-N'-{4-[3-(trityloxy)propoxy]phenyl}-1,1'-biphenyl-4,4'-diamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 93 percent / K₂CO₃ / dimethylformamide / 20 °C

2.1: DMAP; pyridine / 32 h / 70 °C

3.1: DPPF / Pd₂(dba)3 / toluene / 0.17 h

3.2: 83 percent / t-BuONa / toluene / 90 °C

4.1: DPPF / Pd₂(dba)3 / toluene / 0.17 h

4.2: 92 percent / t-BuONa / toluene / 90 °C

With pyridine; dmap; 1,1'-bis-(diphenylphosphino)ferrocene; potassium carbonate; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In N,N-dimethyl-formamide; toluene;
DOI:10.1055/s-2002-32533