2-((6-((5-amino-2-methoxyphenyl)amino)-3-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-methylbenzamide

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Chemical Name:2-((6-((5-amino-2-methoxyphenyl)amino)-3-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-methylbenzamide
CAS No.:1346448-00-7
Molecular Formula:C₂₆H₃₀N₈O₃
Molecular Weight:502.576
Hs Code.:

Synonyms:2-((6-((5-amino-2-methoxyphenyl)amino)-3-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-methylbenzamide

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Chemical Property of 2-((6-((5-amino-2-methoxyphenyl)amino)-3-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-methylbenzamide

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Technology Process of 2-((6-((5-amino-2-methoxyphenyl)amino)-3-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-methylbenzamide

There total 7 articles about 2-((6-((5-amino-2-methoxyphenyl)amino)-3-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.8%

: 1346447-99-1
2-((6-((2-methoxy-5-nitrophenyl)amino)-3-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-methylbenzamide

: 1346448-00-7
2-((6-((5-amino-2-methoxyphenyl)amino)-3-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethyl acetate; at 20 ℃;

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 1346448-00-7
2-((6-((5-amino-2-methoxyphenyl)amino)-3-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / ethyl acetate / 20 °C

2: potassium tert-butylate / N,N-dimethyl-formamide / 20 °C

3: potassium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / tert-butyl alcohol / 14 h / 90 °C / Inert atmosphere

4: hydrogen / palladium 10% on activated carbon / ethyl acetate / 20 °C

With potassium tert-butylate; hydrogen; potassium carbonate; toluene-4-sulfonic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; XPhos; In ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 118-48-9
isatoic anhydride

: 1346448-00-7
2-((6-((5-amino-2-methoxyphenyl)amino)-3-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1,4-dioxane / 0.33 h

2: potassium tert-butylate / N,N-dimethyl-formamide / 20 °C

3: potassium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / tert-butyl alcohol / 14 h / 90 °C / Inert atmosphere

4: hydrogen / palladium 10% on activated carbon / ethyl acetate / 20 °C

With potassium tert-butylate; hydrogen; potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; XPhos; In 1,4-dioxane; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol;