2-((6-((2-methoxy-5-nitrophenyl)amino)-3-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-methylbenzamide

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Chemical Name:2-((6-((2-methoxy-5-nitrophenyl)amino)-3-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-methylbenzamide
CAS No.:1346447-99-1
Molecular Formula:C₂₆H₂₈N₈O₅
Molecular Weight:532.559
Hs Code.:

Synonyms:2-((6-((2-methoxy-5-nitrophenyl)amino)-3-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-methylbenzamide

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Chemical Property of 2-((6-((2-methoxy-5-nitrophenyl)amino)-3-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-methylbenzamide

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Technology Process of 2-((6-((2-methoxy-5-nitrophenyl)amino)-3-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-methylbenzamide

There total 6 articles about 2-((6-((2-methoxy-5-nitrophenyl)amino)-3-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.6%

: 1346447-98-0
2-((6-chloro-3-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-methylbenzamide

: 99-59-2
3-amino-4-methoxynitrobenzene

: 1346447-99-1
2-((6-((2-methoxy-5-nitrophenyl)amino)-3-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: With potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In tert-butyl alcohol; at 90 ℃; for 14h; Inert atmosphere;

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 1346447-99-1
2-((6-((2-methoxy-5-nitrophenyl)amino)-3-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / ethyl acetate / 20 °C

2: potassium tert-butylate / N,N-dimethyl-formamide / 20 °C

3: potassium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / tert-butyl alcohol / 14 h / 90 °C / Inert atmosphere

With potassium tert-butylate; potassium carbonate; toluene-4-sulfonic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 118-48-9
isatoic anhydride

: 1346447-99-1
2-((6-((2-methoxy-5-nitrophenyl)amino)-3-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1,4-dioxane / 0.33 h

2: potassium tert-butylate / N,N-dimethyl-formamide / 20 °C

3: potassium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / tert-butyl alcohol / 14 h / 90 °C / Inert atmosphere

With potassium tert-butylate; potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In 1,4-dioxane; N,N-dimethyl-formamide; tert-butyl alcohol;