methyl 3-(2-fluorophenyl)-8-(trifluoromethylsulfonyloxy)-6H-benzo[c]chromene-2-carboxylate

Base Information

Chemical Name:methyl 3-(2-fluorophenyl)-8-(trifluoromethylsulfonyloxy)-6H-benzo[c]chromene-2-carboxylate
CAS No.:1428640-11-2
Molecular Formula:C₂₂H₁₄F₄O₆S
Molecular Weight:482.409
Hs Code.:

Synonyms:methyl 3-(2-fluorophenyl)-8-(trifluoromethylsulfonyloxy)-6H-benzo[c]chromene-2-carboxylate

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Chemical Property of methyl 3-(2-fluorophenyl)-8-(trifluoromethylsulfonyloxy)-6H-benzo[c]chromene-2-carboxylate

Chemical Property:

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Technology Process of methyl 3-(2-fluorophenyl)-8-(trifluoromethylsulfonyloxy)-6H-benzo[c]chromene-2-carboxylate

There total 13 articles about methyl 3-(2-fluorophenyl)-8-(trifluoromethylsulfonyloxy)-6H-benzo[c]chromene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 358-23-6
trifluoromethylsulfonic anhydride

: 1428640-10-1
methyl 3-(2-fluorophenyl)-8-hydroxy-6H-benzo[c]chromene-2-carboxylate

: 1428640-11-2
methyl 3-(2-fluorophenyl)-8-(trifluoromethylsulfonyloxy)-6H-benzo[c]chromene-2-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield:

: 1428639-86-4
methyl 2'-fluoro-5-nitrobiphenyl-2-carboxylate

: 1428640-11-2
methyl 3-(2-fluorophenyl)-8-(trifluoromethylsulfonyloxy)-6H-benzo[c]chromene-2-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: iron; acetic acid / 2 h / 85 °C

2.1: sulfuric acid; water; sodium nitrite / 19 h / 0 - 60 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

3.2: 1 h / 20 °C

4.1: tetrafluoroboric acid; N,N-dimethyl acetamide; palladium diacetate; potassium carbonate; tricyclohexylphosphine / 100 °C / Inert atmosphere

5.1: aluminum (III) chloride / dichloromethane / 1 h / 0 °C / Inert atmosphere

6.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

With aluminum (III) chloride; tetrafluoroboric acid; N,N-dimethyl acetamide; sulfuric acid; water; palladium diacetate; iron; sodium hydride; potassium carbonate; acetic acid; triethylamine; sodium nitrite; tricyclohexylphosphine; In dichloromethane; N,N-dimethyl-formamide; 4.1: |Sonogashira Cross-Coupling;

Reference yield:

: 1428639-88-6
methyl 2'-fluoro-5-hydroxybiphenyl-2-carboxylate

: 1428640-11-2
methyl 3-(2-fluorophenyl)-8-(trifluoromethylsulfonyloxy)-6H-benzo[c]chromene-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

1.2: 1 h / 20 °C

2.1: tetrafluoroboric acid; N,N-dimethyl acetamide; palladium diacetate; potassium carbonate; tricyclohexylphosphine / 100 °C / Inert atmosphere

3.1: aluminum (III) chloride / dichloromethane / 1 h / 0 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

With aluminum (III) chloride; tetrafluoroboric acid; N,N-dimethyl acetamide; palladium diacetate; sodium hydride; potassium carbonate; triethylamine; tricyclohexylphosphine; In dichloromethane; N,N-dimethyl-formamide; 2.1: |Sonogashira Cross-Coupling;