3'-fluoro-4'-pivaloylaminoacetophenone

Base Information

Chemical Name:3'-fluoro-4'-pivaloylaminoacetophenone
CAS No.:130600-30-5
Molecular Formula:C₁₃H₁₆FNO₂
Molecular Weight:237.274
Hs Code.:

Synonyms:3'-fluoro-4'-pivaloylaminoacetophenone

Suppliers and Price of 3'-fluoro-4'-pivaloylaminoacetophenone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3'-fluoro-4'-pivaloylaminoacetophenone

Chemical Property:

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Technology Process of 3'-fluoro-4'-pivaloylaminoacetophenone

There total 5 articles about 3'-fluoro-4'-pivaloylaminoacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 130600-30-5
3'-fluoro-4'-pivaloylaminoacetophenone

Guidance literature:

Reference yield: 66.0%

: 127-19-5,116057-81-9
N,N-dimethyl acetamide

: 165180-44-9
N-(4-bromo-2-fluorophenyl)pivalamide

: 130600-30-5
3'-fluoro-4'-pivaloylaminoacetophenone

Guidance literature:: With n-butyllithium; In tetrahydrofuran; at -78 ℃;
DOI:10.1021/jm9700326

Reference yield:

: 367-24-8
4-bromo-2-fluoroaniline

: 130600-30-5
3'-fluoro-4'-pivaloylaminoacetophenone

Guidance literature:: Multi-step reaction with 2 steps

1: piridine / 0.17 h / 0 °C

2: 1.) PdCl₂(PPh₃)2, 2.) 2M aq. HCl / 1.) toluene, 10 deg C, 8 h, 2.) toluene, RT, overnight

With pyridine; hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride;
DOI:10.1055/s-1997-1379