6,8-Difluoro-2-(3-fluoro-4-pivaloylaminophenyl)-5-pivaloylamino-4H-1-benzopyran-4-one

Base Information

• Chemical Name: 6,8-Difluoro-2-(3-fluoro-4-pivaloylaminophenyl)-5-pivaloylamino-4H-1-benzopyran-4-one
• CAS No.: 152835-71-7
• Molecular Formula: C₂₅H₂₅F₃N₂O₄
• Molecular Weight: 474.48
• Mol file: 152835-71-7.mol

Synonyms:6,8-Difluoro-2-(3-fluoro-4-pivaloylaminophenyl)-5-pivaloylamino-4H-1-benzopyran-4-one

Chemical Property of 6,8-Difluoro-2-(3-fluoro-4-pivaloylaminophenyl)-5-pivaloylamino-4H-1-benzopyran-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6,8-Difluoro-2-(3-fluoro-4-pivaloylaminophenyl)-5-pivaloylamino-4H-1-benzopyran-4-one

There total 21 articles about 6,8-Difluoro-2-(3-fluoro-4-pivaloylaminophenyl)-5-pivaloylamino-4H-1-benzopyran-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3'-fluoro-4'-pivaloylaminoacetophenone (130600-30-5) + ethyl 3,5-difluoro-6-(N-ethoxycarbonyl-N-pivaloylamino)-2-methoxymethoxybenzoate (152835-59-1) → 6,8-Difluoro-2-(3-fluoro-4-pivaloylaminophenyl)-5-pivaloylamino-4H-1-benzopyran-4-one (152835-71-7)

Guidance literature:

With hydrogenchloride; sodium chloride; In 1,4-dioxane; ethanol; water;

Reference yield:

pivaloyl chloride (3282-30-2) → 6,8-Difluoro-2-(3-fluoro-4-pivaloylaminophenyl)-5-pivaloylamino-4H-1-benzopyran-4-one (152835-71-7)

Guidance literature:

Multi-step reaction with 3 steps

1: piridine / 0.17 h / 0 °C

2: 1.) PdCl₂(PPh₃)2, 2.) 2M aq. HCl / 1.) toluene, 10 deg C, 8 h, 2.) toluene, RT, overnight

3: 1.) NaH, 2.) conc. HCl, 3.) TBAF

With pyridine; hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; tetrabutyl ammonium fluoride; sodium hydride;

DOI:10.1055/s-1997-1379

Reference yield:

4-bromo-2-fluoroaniline (367-24-8) → 6,8-Difluoro-2-(3-fluoro-4-pivaloylaminophenyl)-5-pivaloylamino-4H-1-benzopyran-4-one (152835-71-7)

Guidance literature:

Multi-step reaction with 3 steps

1: piridine / 0.17 h / 0 °C

2: 1.) PdCl₂(PPh₃)2, 2.) 2M aq. HCl / 1.) toluene, 10 deg C, 8 h, 2.) toluene, RT, overnight

3: 1.) NaH, 2.) conc. HCl, 3.) TBAF

With pyridine; hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; tetrabutyl ammonium fluoride; sodium hydride;

DOI:10.1055/s-1997-1379

upstream raw materials:

N-(2-{3-[4-(2,2-Dimethyl-propionylamino)-3-fluoro-phenyl]-3-oxo-propionyl}-4,6-difluoro-3-methoxymethoxy-phenyl)-2,2-dimethyl-propionamide

3'-fluoro-4'-pivaloylaminoacetophenone

ethyl 3,5-difluoro-6-pivaloylamino-2-(2-tetrahydropyranyloxy)-4-trimethylsilylbenzoate

2,4-difluorophenol

Downstream raw materials:

5-amino-2-(4-amino-3-fluorophenyl)-6,8-difluoro-4H-1-benzopyran-4-one

7-ethoxycarbonyl-6,8-difluoro-2-(3-fluoro-4-pivaloylaminophenyl)-5-pivaloylamino-4H-1-benzopyran-4-one

7-azido-6,8-difluoro-2-(3-fluoro-4-pivaloylaminophenyl)-5-pivaloylamino-4H-1-benzopyran-4-one

7-amino-6,8-difluoro-2-(3-fluoro-4-pivaloylaminophenyl)-5-pivaloylamino-4H-1-benzopyran-4-one