ethyl 3-chloro-4-(5-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-1,2,4-oxadiazol-3-yl)benzoate

Base Information

Chemical Name:ethyl 3-chloro-4-(5-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-1,2,4-oxadiazol-3-yl)benzoate
CAS No.:1228375-18-5
Molecular Formula:C₁₉H₁₁Cl₂F₃N₄O₃
Molecular Weight:471.223
Hs Code.:

Synonyms:ethyl 3-chloro-4-(5-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-1,2,4-oxadiazol-3-yl)benzoate

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Chemical Property of ethyl 3-chloro-4-(5-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-1,2,4-oxadiazol-3-yl)benzoate

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Technology Process of ethyl 3-chloro-4-(5-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-1,2,4-oxadiazol-3-yl)benzoate

There total 1 articles about ethyl 3-chloro-4-(5-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-1,2,4-oxadiazol-3-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1228376-16-6
ethyl 3-chloro-4-(N'-hydroxycarbamimidoyl)benzoate

: 353258-35-2
8-chloro-6-(trifluoromethyl)-imidazo[1,2-a]pyridine-2-carboxylic acid

: 1228375-18-5
ethyl 3-chloro-4-(5-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-1,2,4-oxadiazol-3-yl)benzoate

Guidance literature:: 8-chloro-6-(trifluoromethyl)-imidazo[1,2-a]pyridine-2-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

ethyl 3-chloro-4-(N'-hydroxycarbamimidoyl)benzoate; In N,N-dimethyl-formamide; at 100 ℃; for 12h;

Reference yield: 80.0%

: 1228375-18-5
ethyl 3-chloro-4-(5-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-1,2,4-oxadiazol-3-yl)benzoate

: 1228375-19-6
3-chloro-4-(5-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-1,2,4-oxadiazol-3-yl)benzoic acid

Guidance literature:: ethyl 3-chloro-4-(5-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-1,2,4-oxadiazol-3-yl)benzoate; With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 2h;

With hydrogenchloride; In water; pH=5;

Reference yield: 70.0%

: 1228375-18-5
ethyl 3-chloro-4-(5-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-1,2,4-oxadiazol-3-yl)benzoate

: 1228376-17-7
(3-chloro-4-(5-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-1,2,4-oxadiazol-3-yl)phenyl)methanol

Guidance literature:: ethyl 3-chloro-4-(5-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-1,2,4-oxadiazol-3-yl)benzoate; With diisobutylaluminium hydride; In dichloromethane; at 0 ℃;

With water; ammonium chloride; In dichloromethane; ethyl acetate; at -40 ℃;