-2-(methoxycarbonyl)amino-4-phenyl-3-butenoic acid

Base Information

Chemical Name:-2-(methoxycarbonyl)amino-4-phenyl-3-butenoic acid
CAS No.:136978-25-1
Molecular Formula:C₁₂H₁₃NO₄
Molecular Weight:235.24
Hs Code.:

<S-(E)>-2-(methoxycarbonyl)amino-4-phenyl-3-butenoic acid

Synonyms:-2-(methoxycarbonyl)amino-4-phenyl-3-butenoic acid

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Chemical Property of -2-(methoxycarbonyl)amino-4-phenyl-3-butenoic acid

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Technology Process of -2-(methoxycarbonyl)amino-4-phenyl-3-butenoic acid

There total 5 articles about -2-(methoxycarbonyl)amino-4-phenyl-3-butenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 99259-18-4
(R)-3-Iodo-2-<(methoxycarbonyl)amino>propanoic Acid Benzyl Ester

: 136978-25-1
-2-(methoxycarbonyl)amino-4-phenyl-3-butenoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / toluene / 120 h / 50 °C

2: 1.) Amberlyst A-26 (Cl^-), 2.) hydrogen / 2.) 10percent Pd/C / 1.) aq. EtOH; 2.) EtOH, 1 atm, 21 h

3: 1.) n-BuLi / 1.) THF-HMPA, hexane, dry-ice/acetone-bath; 2.) -78 to 0 deg C, 17 min

With n-butyllithium; Amberlyst A-26 (Cl^-); hydrogen; palladium on activated charcoal; In toluene;
DOI:10.1248/cpb.39.1407

Reference yield:

: 99259-17-3
(S)-N-(Methoxycarbonyl)serine Benzyl Ester

: 136978-25-1
-2-(methoxycarbonyl)amino-4-phenyl-3-butenoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 65 percent / pyridine / 3 h / -10 °C

2: 100 percent / NaI / acetone / 72 h / Ambient temperature

3: 97 percent / toluene / 120 h / 50 °C

4: 1.) Amberlyst A-26 (Cl^-), 2.) hydrogen / 2.) 10percent Pd/C / 1.) aq. EtOH; 2.) EtOH, 1 atm, 21 h

5: 1.) n-BuLi / 1.) THF-HMPA, hexane, dry-ice/acetone-bath; 2.) -78 to 0 deg C, 17 min

With pyridine; n-butyllithium; Amberlyst A-26 (Cl^-); hydrogen; sodium iodide; palladium on activated charcoal; In acetone; toluene;
DOI:10.1248/cpb.39.1407

Reference yield:

: 136978-32-0
(S)-N-(Methoxycarbonyl)-O-(p-toluenesulfonyl)serine Benzyl Ester

: 136978-25-1
-2-(methoxycarbonyl)amino-4-phenyl-3-butenoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / NaI / acetone / 72 h / Ambient temperature

2: 97 percent / toluene / 120 h / 50 °C

3: 1.) Amberlyst A-26 (Cl^-), 2.) hydrogen / 2.) 10percent Pd/C / 1.) aq. EtOH; 2.) EtOH, 1 atm, 21 h

4: 1.) n-BuLi / 1.) THF-HMPA, hexane, dry-ice/acetone-bath; 2.) -78 to 0 deg C, 17 min

With n-butyllithium; Amberlyst A-26 (Cl^-); hydrogen; sodium iodide; palladium on activated charcoal; In acetone; toluene;
DOI:10.1248/cpb.39.1407