[4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[1-(2-methoxy-ethyl)-4-(1-propyl-1H-pyrazol-4-yl)-1H-indol-3-yl]-methanone hydrochloride

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Chemical Name:[4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[1-(2-methoxy-ethyl)-4-(1-propyl-1H-pyrazol-4-yl)-1H-indol-3-yl]-methanone hydrochloride
CAS No.:1313040-83-3
Molecular Formula:C₃₀H₃₆FN₅O₂*ClH
Molecular Weight:554.107
Hs Code.:

Synonyms:[4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[1-(2-methoxy-ethyl)-4-(1-propyl-1H-pyrazol-4-yl)-1H-indol-3-yl]-methanone hydrochloride

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Chemical Property of [4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[1-(2-methoxy-ethyl)-4-(1-propyl-1H-pyrazol-4-yl)-1H-indol-3-yl]-methanone hydrochloride

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Technology Process of [4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[1-(2-methoxy-ethyl)-4-(1-propyl-1H-pyrazol-4-yl)-1H-indol-3-yl]-methanone hydrochloride

There total 2 articles about [4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[1-(2-methoxy-ethyl)-4-(1-propyl-1H-pyrazol-4-yl)-1H-indol-3-yl]-methanone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1313043-67-2
2,2,2-trifluoro-N-(4-fluoro-3-{1-[1-(2-methoxy-ethyl)-4-(1-propyl-1H-pyrazol-4-yl)-1H-indole-3-carbonyl]-piperidin-4-yl}-benzyl)-acetamide

: 1313040-83-3
[4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[1-(2-methoxy-ethyl)-4-(1-propyl-1H-pyrazol-4-yl)-1H-indol-3-yl]-methanone hydrochloride

Guidance literature:: 2,2,2-trifluoro-N-(4-fluoro-3-{1-[1-(2-methoxy-ethyl)-4-(1-propyl-1H-pyrazol-4-yl)-1H-indole-3-carbonyl]-piperidin-4-yl}-benzyl)-acetamide; With water; potassium carbonate; In methanol; at 45 ℃; for 2h;

With hydrogenchloride; In 1,4-dioxane;

Reference yield:

: 1313043-12-7
N-(3-{1-[4-bromo-1-(2-methoxy-ethyl)-1H-indole-3-carbonyl]-piperidin-4-yl}-4-fluoro-benzyl)-2,2,2-trifluoro-acetamide

: 847818-57-9
(1-propyl-1H-pyrazol-4-yl)boronic acid

: 1313040-83-3
[4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[1-(2-methoxy-ethyl)-4-(1-propyl-1H-pyrazol-4-yl)-1H-indol-3-yl]-methanone hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 80 °C

2: potassium carbonate; water / methanol / 2 h / 45 °C

With water; potassium carbonate; caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; methanol; water;