2-<(S)-1-t-butyloxycarbonylamino-2-phenyl-ethyl>-4-methoxycarbonyl-(R)-Δ2-thiazoline

Base Information

• Chemical Name: 2-<(S)-1-t-butyloxycarbonylamino-2-phenyl-ethyl>-4-methoxycarbonyl-(R)-Δ2-thiazoline
• CAS No.: 132402-66-5
• Molecular Formula: C₁₈H₂₄N₂O₄S
• Molecular Weight: 364.466
• Mol file: 132402-66-5.mol

Synonyms:2-<(S)-1-t-butyloxycarbonylamino-2-phenyl-ethyl>-4-methoxycarbonyl-(R)-Δ2-thiazoline

Chemical Property of 2-<(S)-1-t-butyloxycarbonylamino-2-phenyl-ethyl>-4-methoxycarbonyl-(R)-Δ2-thiazoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-<(S)-1-t-butyloxycarbonylamino-2-phenyl-ethyl>-4-methoxycarbonyl-(R)-Δ2-thiazoline

There total 8 articles about 2-<(S)-1-t-butyloxycarbonylamino-2-phenyl-ethyl>-4-methoxycarbonyl-(R)-Δ2-thiazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-thiopropionylamino)-3-hydroxy-propionic acid methyl ester (142342-82-3) → (S)-2-((S)-1-tert-Butoxycarbonylamino-2-phenyl-ethyl)-4,5-dihydro-thiazole-4-carboxylic acid methyl ester (132402-66-5)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; Ambient temperature;

DOI:10.1016/S0040-4039(00)78864-2

Reference yield: 27.0%

L-cysteine methyl ester hydrochloride (18598-63-5) + 2(S)--3-phenylpropanimino ethyl ether (132402-59-6) → 2-<(S)-1-t-butyloxycarbonylamino-2-phenyl-ethyl>-4-methoxycarbonyl-(R)-Δ2-thiazoline (132402-66-5)

Guidance literature:

In ethanol; for 4h; Ambient temperature;

DOI:10.1016/S0040-4020(01)81482-4

Reference yield:

C18H24N4O5S (940950-77-6) → 2-<(S)-1-t-butyloxycarbonylamino-2-phenyl-ethyl>-4-methoxycarbonyl-(R)-Δ2-thiazoline (132402-66-5)

Guidance literature:

With triphenylphosphine; In tetrahydrofuran; at -20 - 20 ℃; for 2h;

DOI:10.1002/anie.200604507

upstream raw materials:

L-cysteine methyl ester hydrochloride

2(S)--3-phenylpropanimino ethyl ether

(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-thiopropionylamino)-3-hydroxy-propionic acid methyl ester

C₁₈H₂₄N₄O₅S

Downstream raw materials:

2-<(S)-1-t-butyloxycarbonylamino-2-phenyl-ethyl>-4-carboxythiazole

2-<(S)-1-t-butyloxycarbonylamino-2-phenyl-ethyl>-4-methoxycarbonylthiazole