132402-59-6

Upstream product

• 88463-18-7 (S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropionamide 
• 17950-40-2 triethyloxonium hexaflourophosphate 
• 63-91-2 L-phenylalanine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 

Downstream Products

• 132402-66-5 2-<(S)-1-t-butyloxycarbonylamino-2-phenyl-ethyl>-4-methoxycarbonyl-(R)-Δ2-thiazoline 
• 132402-74-5 2-<(S)-1-t-butyloxycarbonylamino-2-phenyl-ethyl>-4-methoxycarbonylthiazole 
• 131148-64-6 (S)-ethyl 2-(1-(tert-butoxycarbonylamino)-2-phenylethyl)thiazole-4-carboxylate 
• 161006-71-9 (S)-2-{[2-((S)-1-tert-Butoxycarbonylamino-2-phenyl-ethyl)-thiazole-4-carbonyl]-amino}-3-phenyl-propionic acid methyl ester 
• 276680-02-5 Boc-(S)-Phe-Thz-Phe-Pro-OMe 
• 161006-69-5 Boc-(S)-Phe-Thz-(S)-Pro-aThr-(R)-Val-Thz-OMe 
• 161006-68-4 C₃₈H₄₃N₇O₆S₂ 
• 120853-17-0 lissoclinamide 5 
• 132402-81-4 2-<(S)-1-t-butyloxycarbonylamino-2-phenyl-ethyl>-4-carboxythiazole 

Relevant academic research and scientific papers

Oxidation of oxazolines and thiazolines to oxazoles and thiazoles. Application of the Kharasch-Sosnovsky reaction

Using a modification of the Kharasch-Sosnovsky reaction, the oxidation of oxazolines and thiazolines bearing a variety of 2-alkyl substituents (chiral and achiral) were smoothly oxidized to their corresponding oxazoles and thiazoles, respectively. The key feature involved in the successful implementation of this important oxidation was the use of a mixture of Cu(I) and Cu(II) salts to enhance the oxidation of the intermediate captodative radical, 24. The main limitation of this method was shown when the oxidation failed with oxazolines/thiazolines lacking the carboalkoxy group at C-4.

Synthetic studies towards cyclic peptides. Concise synthesis of thiazoline and thiazole containing amino acids

Concise and efficient syntheses of optically pure thiazoline and thiazole containing amino acids of the constitution (26) and (27), based on simple condensation reactions between cysteine esters and N-protected imino ethers (22) and (25) derived from chir