(2S,4S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-4-((2S,4S)-4-isopropyl-5-(4-methoxy-3-(3-methoxypropoxy)phenyl)pyrrolidin-2-yl)butanamide

Base Information

Chemical Name:(2S,4S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-4-((2S,4S)-4-isopropyl-5-(4-methoxy-3-(3-methoxypropoxy)phenyl)pyrrolidin-2-yl)butanamide
CAS No.:1364791-17-2
Molecular Formula:C₃₀H₅₁N₃O₆
Molecular Weight:549.751
Hs Code.:

(2S,4S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-4-((2S,4S)-4-isopropyl-5-(4-methoxy-3-(3-methoxypropoxy)phenyl)pyrrolidin-2-yl)butanamide

Synonyms:(2S,4S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-4-((2S,4S)-4-isopropyl-5-(4-methoxy-3-(3-methoxypropoxy)phenyl)pyrrolidin-2-yl)butanamide

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Chemical Property of (2S,4S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-4-((2S,4S)-4-isopropyl-5-(4-methoxy-3-(3-methoxypropoxy)phenyl)pyrrolidin-2-yl)butanamide

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Technology Process of (2S,4S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-4-((2S,4S)-4-isopropyl-5-(4-methoxy-3-(3-methoxypropoxy)phenyl)pyrrolidin-2-yl)butanamide

There total 5 articles about (2S,4S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-4-((2S,4S)-4-isopropyl-5-(4-methoxy-3-(3-methoxypropoxy)phenyl)pyrrolidin-2-yl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1364791-13-8
(2S,4S,5S,7S)-4-amino-7-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-5-hydroxy-2-isopropyl-1-(4-methoxy-3-(3-methoxypropoxy)phenyl)-8-methylnonyl isobutyrate

: 1364791-17-2
(2S,4S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-4-((2S,4S)-4-isopropyl-5-(4-methoxy-3-(3-methoxypropoxy)phenyl)pyrrolidin-2-yl)butanamide

Guidance literature:: (2S,4S,5S,7S)-4-amino-7-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-5-hydroxy-2-isopropyl-1-(4-methoxy-3-(3-methoxypropoxy)phenyl)-8-methylnonyl isobutyrate; With sulfuric acid; In toluene; at 20 ℃;

With sodium carbonate; In 2-methyltetrahydrofuran; toluene; pH=8.5;

Reference yield:

: 1315181-73-7
(2S,4S)-4-azido-2-isopropyl-4-((2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl)-1-(4-methoxy-3-(3-methoxypropoxy)phenyl)butyl isobutyrate

: 1364791-17-2
(2S,4S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-4-((2S,4S)-4-isopropyl-5-(4-methoxy-3-(3-methoxypropoxy)phenyl)pyrrolidin-2-yl)butanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 88 °C

2.1: ammonium formate / palladium 10% on activated carbon / ethanol; water / 48 h

3.1: sulfuric acid / toluene / 20 °C

3.2: pH 8.5

With sulfuric acid; ammonium formate; palladium 10% on activated carbon; In ethanol; water; toluene;

Reference yield:

: 1315181-75-9
(2S,4S,5S,7S)-7-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-4-azido-5-hydroxy-2-isopropyl-1-(4-methoxy-3-(3-methoxypropoxy)-phenyl)-8-methylnonyl isobutyrate

: 1364791-17-2
(2S,4S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-4-((2S,4S)-4-isopropyl-5-(4-methoxy-3-(3-methoxypropoxy)phenyl)pyrrolidin-2-yl)butanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonium formate / palladium 10% on activated carbon / ethanol; water / 48 h

2.1: sulfuric acid / toluene / 20 °C

2.2: pH 8.5

With sulfuric acid; ammonium formate; palladium 10% on activated carbon; In ethanol; water; toluene;