(2-allyl-1-benzenesulfonyl-3-bromo-piperidin-3-yl)-acetic acid ethyl ester

Base Information

Chemical Name:(2-allyl-1-benzenesulfonyl-3-bromo-piperidin-3-yl)-acetic acid ethyl ester
CAS No.:1335288-19-1
Molecular Formula:C₁₈H₂₄BrNO₄S
Molecular Weight:430.363
Hs Code.:

Synonyms:(2-allyl-1-benzenesulfonyl-3-bromo-piperidin-3-yl)-acetic acid ethyl ester

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Chemical Property of (2-allyl-1-benzenesulfonyl-3-bromo-piperidin-3-yl)-acetic acid ethyl ester

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Technology Process of (2-allyl-1-benzenesulfonyl-3-bromo-piperidin-3-yl)-acetic acid ethyl ester

There total 2 articles about (2-allyl-1-benzenesulfonyl-3-bromo-piperidin-3-yl)-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1268245-93-7
(1-benzenesulfonyl-1,4,5,6-tetrahydro-pyridin-3-yl)-acetic acid ethyl ester

: 762-72-1
allyl-trimethyl-silane

: 1335288-19-1
(2-allyl-1-benzenesulfonyl-3-bromo-piperidin-3-yl)-acetic acid ethyl ester

Guidance literature:: With N-Bromosuccinimide; boron trifluoride diethyl etherate; In dichloromethane; at 20 ℃; for 5.08333h; Inert atmosphere; Cooling with ice;
DOI:10.1016/j.tet.2011.08.025

Reference yield:

: C₁₅H₁₉NO₄S

: 1335288-19-1
(2-allyl-1-benzenesulfonyl-3-bromo-piperidin-3-yl)-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 2 h / Inert atmosphere; Reflux

2: N-Bromosuccinimide; boron trifluoride diethyl etherate / dichloromethane / 5.08 h / 20 °C / Inert atmosphere; Cooling with ice

With N-Bromosuccinimide; boron trifluoride diethyl etherate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tet.2011.08.025

Reference yield:

: 1335288-19-1
(2-allyl-1-benzenesulfonyl-3-bromo-piperidin-3-yl)-acetic acid ethyl ester

: 4594-82-5,39494-05-8,51501-54-3,147731-69-9
(+/-)-trans-octahydro[1]pyrindine

Guidance literature:: Multi-step reaction with 6 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran / 5 h / 20 °C / Inert atmosphere; Cooling with ice

1.2: Inert atmosphere; Saturated solution; Cooling with ice

2.1: pyridine / dichloromethane / 5 h / 20 °C / Inert atmosphere

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 2 h / Inert atmosphere; Reflux

4.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / 1,2-dichloro-ethane / 1 h / Inert atmosphere; Reflux

5.1: 20 % Pd(OH)2/C; hydrogen

6.1: methanol; magnesium / 4 h / Reflux

With pyridine; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; methanol; 20 % Pd(OH)2/C; hydrogen; diisobutylaluminium hydride; magnesium; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/j.tet.2011.08.025