tert-butyl {[5-(benzyloxy)pyridin-3-yl](phenylsulfonyl)methyl}carbamate

Base Information

• Chemical Name: tert-butyl {[5-(benzyloxy)pyridin-3-yl](phenylsulfonyl)methyl}carbamate
• CAS No.: 1423134-79-5
• Molecular Formula: C₂₄H₂₆N₂O₅S
• Molecular Weight: 454.547
• Mol file: 1423134-79-5.mol

Synonyms:tert-butyl {[5-(benzyloxy)pyridin-3-yl](phenylsulfonyl)methyl}carbamate

Chemical Property of tert-butyl {[5-(benzyloxy)pyridin-3-yl](phenylsulfonyl)methyl}carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl {[5-(benzyloxy)pyridin-3-yl](phenylsulfonyl)methyl}carbamate

There total 1 articles about tert-butyl {[5-(benzyloxy)pyridin-3-yl](phenylsulfonyl)methyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl carbazate (4248-19-5) + sodium benzenesulfonate (873-55-2) + 5-(benzyloxy)pyridine-3-carbaldehyde (263270-32-2) → tert-butyl {[5-(benzyloxy)pyridin-3-yl](phenylsulfonyl)methyl}carbamate (1423134-79-5)

Guidance literature:

With formic acid; In tetrahydrofuran; water; for 144h;

Reference yield:

methyl t-butyl malonate (42726-73-8) + tert-butyl {[5-(benzyloxy)pyridin-3-yl](phenylsulfonyl)methyl}carbamate (1423134-79-5) → tert-butyl methyl 2-{(S)-[5-(benzyloxy)pyridin-3-yl][(tert-butoxycarbonyl)amino]methyl}propanedioate

Guidance literature:

With caesium carbonate; 1-{3,5-bis(trifluoromethyl)phenyl}-3-{(1R,2R)-2-(dimethylamino)cyclohexyl}thiourea; In water; toluene; at 0 - 5 ℃; for 120h;

Reference yield:

tert-butyl {[5-(benzyloxy)pyridin-3-yl](phenylsulfonyl)methyl}carbamate (1423134-79-5) → 2-[(S)-amino-5-(benzyloxy)pyridin-3-ylmethyl]malonic acid monomethyl ester (1423134-83-1)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate; 1-{3,5-bis(trifluoromethyl)phenyl}-3-{(1R,2R)-2-(dimethylamino)cyclohexyl}thiourea / water; toluene / 120 h / 0 - 5 °C

2: hydrogenchloride / 1,4-dioxane / 20 h

With hydrogenchloride; caesium carbonate; 1-{3,5-bis(trifluoromethyl)phenyl}-3-{(1R,2R)-2-(dimethylamino)cyclohexyl}thiourea; In 1,4-dioxane; water; toluene;

upstream raw materials:

tert-butyl carbazate

sodium benzenesulfonate

5-(benzyloxy)pyridine-3-carbaldehyde

Downstream raw materials:

tert-butyl 4-{3-[(3R)-3-({(1S)-3-methoxy-1-[5-(2-{[(4-methylphenyl)sulfonyl]oxy}ethoxy)pyridin-3-yl]-3-oxopropyl}carbamoyl)piperidin-1-yl]-3-oxopropyl}piperidine-1-carboxylate

tert-butyl 4-{3-[(3R)-3-{[(1S)-1-{5-[(3-bromo-4-cyanobenzyl)oxy]pyridin-3-yl}-3-methoxy-3-oxopropyl]carbamoyl}piperidin-1-yl]-3-oxopropyl}piperidine-1-carboxylate

2-[(S)-amino-5-(benzyloxy)pyridin-3-ylmethyl]malonic acid monomethyl ester

tert-butyl 4-{3-[(3R)-3-({(1S)-1-[5-(benzyloxy)pyridin-3-yl]-3-methoxy-3-oxopropyl}carbamoyl)piperidin-1-yl]-3-oxopropyl}piperidine-1-carboxylate