2-[(S)-amino-5-(benzyloxy)pyridin-3-ylmethyl]malonic acid monomethyl ester

Base Information

Chemical Name:2-[(S)-amino-5-(benzyloxy)pyridin-3-ylmethyl]malonic acid monomethyl ester
CAS No.:1423134-83-1
Molecular Formula:C₁₇H₁₈N₂O₅
Molecular Weight:330.34
Hs Code.:

Synonyms:2-[(S)-amino-5-(benzyloxy)pyridin-3-ylmethyl]malonic acid monomethyl ester

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Chemical Property of 2-[(S)-amino-5-(benzyloxy)pyridin-3-ylmethyl]malonic acid monomethyl ester

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Technology Process of 2-[(S)-amino-5-(benzyloxy)pyridin-3-ylmethyl]malonic acid monomethyl ester

There total 3 articles about 2-[(S)-amino-5-(benzyloxy)pyridin-3-ylmethyl]malonic acid monomethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: tert-butyl methyl 2-{(S)-[5-(benzyloxy)pyridin-3-yl][(tert-butoxycarbonyl)amino]methyl}propanedioate

: 1423134-83-1
2-[(S)-amino-5-(benzyloxy)pyridin-3-ylmethyl]malonic acid monomethyl ester

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; for 20h;

Reference yield:

: 1423134-79-5
tert-butyl {[5-(benzyloxy)pyridin-3-yl](phenylsulfonyl)methyl}carbamate

: 1423134-83-1
2-[(S)-amino-5-(benzyloxy)pyridin-3-ylmethyl]malonic acid monomethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate; 1-{3,5-bis(trifluoromethyl)phenyl}-3-{(1R,2R)-2-(dimethylamino)cyclohexyl}thiourea / water; toluene / 120 h / 0 - 5 °C

2: hydrogenchloride / 1,4-dioxane / 20 h

With hydrogenchloride; caesium carbonate; 1-{3,5-bis(trifluoromethyl)phenyl}-3-{(1R,2R)-2-(dimethylamino)cyclohexyl}thiourea; In 1,4-dioxane; water; toluene;

Reference yield:

: 263270-32-2
5-(benzyloxy)pyridine-3-carbaldehyde

: 1423134-83-1
2-[(S)-amino-5-(benzyloxy)pyridin-3-ylmethyl]malonic acid monomethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: formic acid / tetrahydrofuran; water / 144 h

2: caesium carbonate; 1-{3,5-bis(trifluoromethyl)phenyl}-3-{(1R,2R)-2-(dimethylamino)cyclohexyl}thiourea / water; toluene / 120 h / 0 - 5 °C

3: hydrogenchloride / 1,4-dioxane / 20 h

With hydrogenchloride; formic acid; caesium carbonate; 1-{3,5-bis(trifluoromethyl)phenyl}-3-{(1R,2R)-2-(dimethylamino)cyclohexyl}thiourea; In tetrahydrofuran; 1,4-dioxane; water; toluene;