Technology Process of Quinestrol
There total 7 articles about Quinestrol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
trimethylsilylacetylene;
With
n-butyllithium;
In
tetrahydrofuran;
at -20 ℃;
for 0.5h;
Inert atmosphere;
estrone 3-cyclopentyl ether;
In
tetrahydrofuran;
at -20 ℃;
for 1h;
Inert atmosphere;
With
potassium hydroxide;
In
tetrahydrofuran; methanol;
at 20 ℃;
for 0.5h;
DOI:10.1016/j.tet.2016.03.002
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: acetic anhydride; dmap / Green chemistry
1.2: Green chemistry
1.3: Green chemistry
2.1: n-butyllithium / tetrahydrofuran / 0.5 h / -20 °C / Inert atmosphere
2.2: 1 h / -20 °C / Inert atmosphere
2.3: 0.5 h / 20 °C
With
dmap; n-butyllithium; acetic anhydride;
In
tetrahydrofuran;
DOI:10.1016/j.tet.2016.03.002
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: trifluorormethanesulfonic acid / isopropyl alcohol / 2 h / 100 °C / Inert atmosphere; Green chemistry
2.1: n-butyllithium / tetrahydrofuran / 0.5 h / -20 °C / Inert atmosphere
2.2: 1 h / -20 °C / Inert atmosphere
2.3: 0.5 h / 20 °C
With
n-butyllithium; trifluorormethanesulfonic acid;
In
tetrahydrofuran; isopropyl alcohol;
DOI:10.1016/j.tet.2016.03.002
