(S)-3-{(S)-2-[(S)-2-(2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-sulfooxy-phenyl)-propionylamino]-hexanoylamino}-acetylamino)-3-naphthalen-1-yl-propionylamino]-hexanoylamino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid

Base Information

Chemical Name:(S)-3-{(S)-2-[(S)-2-(2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-sulfooxy-phenyl)-propionylamino]-hexanoylamino}-acetylamino)-3-naphthalen-1-yl-propionylamino]-hexanoylamino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid
CAS No.:136015-56-0
Molecular Formula:C₅₄H₇₀N₈O₁₅S
Molecular Weight:1103.26
Hs Code.:

(S)-3-{(S)-2-[(S)-2-(2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-sulfooxy-phenyl)-propionylamino]-hexanoylamino}-acetylamino)-3-naphthalen-1-yl-propionylamino]-hexanoylamino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid

Synonyms:(S)-3-{(S)-2-[(S)-2-(2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-sulfooxy-phenyl)-propionylamino]-hexanoylamino}-acetylamino)-3-naphthalen-1-yl-propionylamino]-hexanoylamino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid

Suppliers and Price of (S)-3-{(S)-2-[(S)-2-(2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-sulfooxy-phenyl)-propionylamino]-hexanoylamino}-acetylamino)-3-naphthalen-1-yl-propionylamino]-hexanoylamino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of (S)-3-{(S)-2-[(S)-2-(2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-sulfooxy-phenyl)-propionylamino]-hexanoylamino}-acetylamino)-3-naphthalen-1-yl-propionylamino]-hexanoylamino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-3-{(S)-2-[(S)-2-(2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-sulfooxy-phenyl)-propionylamino]-hexanoylamino}-acetylamino)-3-naphthalen-1-yl-propionylamino]-hexanoylamino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid

There total 12 articles about (S)-3-{(S)-2-[(S)-2-(2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-sulfooxy-phenyl)-propionylamino]-hexanoylamino}-acetylamino)-3-naphthalen-1-yl-propionylamino]-hexanoylamino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 136039-63-9
(S)-3-{(S)-2-[(S)-2-(2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-hexanoylamino}-acetylamino)-3-naphthalen-1-yl-propionylamino]-hexanoylamino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid

: 136015-56-0
(S)-3-{(S)-2-[(S)-2-(2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-sulfooxy-phenyl)-propionylamino]-hexanoylamino}-acetylamino)-3-naphthalen-1-yl-propionylamino]-hexanoylamino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid

Guidance literature:: With pyridine-SO₃ complex; In pyridine; N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1016/0223-5234(91)90056-S

Reference yield:

: 5440-57-3
diethyl (N-acetylamino)[(1-naphthyl)methyl]malonate

: 136015-56-0
(S)-3-{(S)-2-[(S)-2-(2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-sulfooxy-phenyl)-propionylamino]-hexanoylamino}-acetylamino)-3-naphthalen-1-yl-propionylamino]-hexanoylamino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid

Guidance literature:: Multi-step reaction with 10 steps

1: 87 percent / 1 M NaOH / aq. ethanol / 6 h / Ambient temperature

2: 94 percent / 0.17 h / 160 °C

3: 97 percent

4: 53 percent / 6 N aq. HCl / 2 h / Heating

5: 100 percent / 0.5 N aq. NaOH / dioxane / pH 10

6: benzotriazolyloxytris(dimethylamino)phosphonium hexafluorophosphate (BOP), NMM / dimethylformamide / 1 h / Ambient temperature

7: 93 percent / H₂ / 10percent Pd/C / dimethylformamide; methanol / 6 h / 760 Torr / Ambient temperature

8: 100 percent / TFA / 0.5 h / Ambient temperature

9: N,N-diisopropylethylamine (DIEA) / dimethylformamide / 3 h / Ambient temperature

10: 67 percent / SO₃-pyridine complex / dimethylformamide; pyridine / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; pyridine-SO₃ complex; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In 1,4-dioxane; pyridine; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(91)90056-S

Reference yield:

: 55447-00-2,76932-48-4,103190-32-5,104882-22-6
(S)-2-tert-butoxycarbonylamino-3-naphthalen-1-yl-propionic acid

: 136015-56-0
(S)-3-{(S)-2-[(S)-2-(2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-sulfooxy-phenyl)-propionylamino]-hexanoylamino}-acetylamino)-3-naphthalen-1-yl-propionylamino]-hexanoylamino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid

Guidance literature:: Multi-step reaction with 5 steps

1: benzotriazolyloxytris(dimethylamino)phosphonium hexafluorophosphate (BOP), NMM / dimethylformamide / 1 h / Ambient temperature

2: 93 percent / H₂ / 10percent Pd/C / dimethylformamide; methanol / 6 h / 760 Torr / Ambient temperature

3: 100 percent / TFA / 0.5 h / Ambient temperature

4: N,N-diisopropylethylamine (DIEA) / dimethylformamide / 3 h / Ambient temperature

5: 67 percent / SO₃-pyridine complex / dimethylformamide; pyridine / Ambient temperature

With 4-methyl-morpholine; pyridine-SO₃ complex; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In pyridine; methanol; N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(91)90056-S