(S)-3-{(S)-2-[(S)-2-(2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-hexanoylamino}-acetylamino)-3-naphthalen-1-yl-propionylamino]-hexanoylamino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid

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Chemical Name:(S)-3-{(S)-2-[(S)-2-(2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-hexanoylamino}-acetylamino)-3-naphthalen-1-yl-propionylamino]-hexanoylamino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid
CAS No.:136039-63-9
Molecular Formula:C₅₄H₇₀N₈O₁₂
Molecular Weight:1023.2
Hs Code.:

(S)-3-{(S)-2-[(S)-2-(2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-hexanoylamino}-acetylamino)-3-naphthalen-1-yl-propionylamino]-hexanoylamino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid

Synonyms:(S)-3-{(S)-2-[(S)-2-(2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-hexanoylamino}-acetylamino)-3-naphthalen-1-yl-propionylamino]-hexanoylamino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid

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Chemical Property of (S)-3-{(S)-2-[(S)-2-(2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-hexanoylamino}-acetylamino)-3-naphthalen-1-yl-propionylamino]-hexanoylamino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid

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Technology Process of (S)-3-{(S)-2-[(S)-2-(2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-hexanoylamino}-acetylamino)-3-naphthalen-1-yl-propionylamino]-hexanoylamino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid

There total 10 articles about (S)-3-{(S)-2-[(S)-2-(2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-hexanoylamino}-acetylamino)-3-naphthalen-1-yl-propionylamino]-hexanoylamino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5440-57-3
diethyl (N-acetylamino)[(1-naphthyl)methyl]malonate

: 136039-63-9
(S)-3-{(S)-2-[(S)-2-(2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-hexanoylamino}-acetylamino)-3-naphthalen-1-yl-propionylamino]-hexanoylamino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid

Guidance literature:: Multi-step reaction with 9 steps

1: 87 percent / 1 M NaOH / aq. ethanol / 6 h / Ambient temperature

2: 94 percent / 0.17 h / 160 °C

3: 97 percent

4: 53 percent / 6 N aq. HCl / 2 h / Heating

5: 100 percent / 0.5 N aq. NaOH / dioxane / pH 10

6: benzotriazolyloxytris(dimethylamino)phosphonium hexafluorophosphate (BOP), NMM / dimethylformamide / 1 h / Ambient temperature

7: 93 percent / H₂ / 10percent Pd/C / dimethylformamide; methanol / 6 h / 760 Torr / Ambient temperature

8: 100 percent / TFA / 0.5 h / Ambient temperature

9: N,N-diisopropylethylamine (DIEA) / dimethylformamide / 3 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(91)90056-S

Reference yield:

: 55447-00-2,76932-48-4,103190-32-5,104882-22-6
(S)-2-tert-butoxycarbonylamino-3-naphthalen-1-yl-propionic acid

: 136039-63-9
(S)-3-{(S)-2-[(S)-2-(2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-hexanoylamino}-acetylamino)-3-naphthalen-1-yl-propionylamino]-hexanoylamino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid

Guidance literature:: Multi-step reaction with 4 steps

1: benzotriazolyloxytris(dimethylamino)phosphonium hexafluorophosphate (BOP), NMM / dimethylformamide / 1 h / Ambient temperature

2: 93 percent / H₂ / 10percent Pd/C / dimethylformamide; methanol / 6 h / 760 Torr / Ambient temperature

3: 100 percent / TFA / 0.5 h / Ambient temperature

4: N,N-diisopropylethylamine (DIEA) / dimethylformamide / 3 h / Ambient temperature

With 4-methyl-morpholine; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(91)90056-S

Reference yield:

: 51684-92-5,5440-48-2
(S)-2-Acetylamino-3-naphthalen-1-yl-propionic acid

: 136039-63-9
(S)-3-{(S)-2-[(S)-2-(2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-hexanoylamino}-acetylamino)-3-naphthalen-1-yl-propionylamino]-hexanoylamino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 53 percent / 6 N aq. HCl / 2 h / Heating

2: 100 percent / 0.5 N aq. NaOH / dioxane / pH 10

3: benzotriazolyloxytris(dimethylamino)phosphonium hexafluorophosphate (BOP), NMM / dimethylformamide / 1 h / Ambient temperature

4: 93 percent / H₂ / 10percent Pd/C / dimethylformamide; methanol / 6 h / 760 Torr / Ambient temperature

5: 100 percent / TFA / 0.5 h / Ambient temperature

6: N,N-diisopropylethylamine (DIEA) / dimethylformamide / 3 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(91)90056-S