2-?[[(5-(Trifluoromethyl)-1H-benzimidazol-2-yl)thio]methyl]benzenamine

Base Information

• Chemical Name: 2-?[[(5-(Trifluoromethyl)-1H-benzimidazol-2-yl)thio]methyl]benzenamine
• CAS No.: 106746-79-6
• Molecular Formula: C₁₅H₁₂F₃N₃S
• Molecular Weight: 323.342
• Mol file: 106746-79-6.mol

Synonyms:2-?[[(5-(Trifluoromethyl)-1H-benzimidazol-2-yl)thio]methyl]benzenamine

Chemical Property of 2-?[[(5-(Trifluoromethyl)-1H-benzimidazol-2-yl)thio]methyl]benzenamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-?[[(5-(Trifluoromethyl)-1H-benzimidazol-2-yl)thio]methyl]benzenamine

There total 6 articles about 2-?[[(5-(Trifluoromethyl)-1H-benzimidazol-2-yl)thio]methyl]benzenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

ortho-(chloromethyl)-aniline (114059-99-3) + 2-mercapto-5-trifluoromethyl-1H-benzimidazole (86604-73-1) → 2-?[[(5-(Trifluoromethyl)-1H-benzimidazol-2-yl)thio]methyl]benzenamine (106746-79-6)

Guidance literature:

In ethanol; for 2h;

DOI:10.1021/jm00401a024

Reference yield:

2-mercapto-5-trifluoromethyl-1H-benzimidazole (86604-73-1) → 2-?[[(5-(Trifluoromethyl)-1H-benzimidazol-2-yl)thio]methyl]benzenamine (106746-79-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH / H₂O; ethanol / 2 h / Ambient temperature

2: 30percent HBr-AcOH / 3 h / Ambient temperature

With sodium hydroxide; hydrogen bromide; acetic acid; In ethanol; water;

DOI:10.1016/0223-5234(91)90024-H

Reference yield:

2-Aminobenzyl alcohol (5344-90-1) → 2-?[[(5-(Trifluoromethyl)-1H-benzimidazol-2-yl)thio]methyl]benzenamine (106746-79-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 82.4 percent / K₂CO₃ / CHCl₃ / 1.) 4 h, 2.) RT, overnight

2: SOCl₂ / benzene / 1 h / Heating

3: NaOH / H₂O; ethanol / 2 h / Ambient temperature

4: 30percent HBr-AcOH / 3 h / Ambient temperature

With sodium hydroxide; thionyl chloride; hydrogen bromide; potassium carbonate; acetic acid; In ethanol; chloroform; water; benzene;

DOI:10.1016/0223-5234(91)90024-H

upstream raw materials:

ortho-(chloromethyl)-aniline

2-mercapto-5-trifluoromethyl-1H-benzimidazole

[2-(5-Trifluoromethyl-1H-benzoimidazol-2-ylsulfanylmethyl)-phenyl]-carbamic acid benzyl ester

2-Aminobenzyl alcohol

Downstream raw materials:

2-?[[(5-(trifluoromethyl)-1H-benzimidazol-2-yl)sulfinyl]methyl]benzenamine;