86604-73-1

Usage

Uses

Used in Pharmaceutical Industry:
5-(TRIFLUOROMETHYL)-1H-BENZO[D]IMIDAZOLE-2-THIOL is used as a key intermediate in the synthesis of pharmaceuticals for its potential antimicrobial, antifungal, and anticancer properties. Its unique chemical structure allows it to target specific biological pathways, making it a promising candidate for the development of new drugs to combat various diseases.
Used in Organic Synthesis:
In the field of organic synthesis, 5-(TRIFLUOROMETHYL)-1H-BENZO[D]IMIDAZOLE-2-THIOL is utilized as a versatile building block for the creation of complex organic molecules. Its reactivity and functional groups enable chemists to construct a wide range of compounds with diverse applications, from pharmaceuticals to materials science.
Used in Antimicrobial Applications:
5-(TRIFLUOROMETHYL)-1H-BENZO[D]IMIDAZOLE-2-THIOL is employed as an antimicrobial agent, leveraging its ability to interact with biological systems to inhibit the growth of harmful microorganisms. This property makes it a valuable component in the development of new antimicrobial drugs and treatments.
Used in Antifungal Applications:
Similarly, in antifungal applications, 5-(TRIFLUOROMETHYL)-1H-BENZO[D]IMIDAZOLE-2-THIOL is used to combat fungal infections. Its potential to disrupt fungal cell processes positions it as a candidate for the development of new antifungal medications.
Used in Anticancer Research:
5-(TRIFLUOROMETHYL)-1H-BENZO[D]IMIDAZOLE-2-THIOL is also used in anticancer research, where it is studied for its potential to target and inhibit the growth of cancer cells. Its unique structure and interactions with biological systems make it a promising compound for the development of novel cancer therapies.
Used in Material Science:
In material science, 5-(TRIFLUOROMETHYL)-1H-BENZO[D]IMIDAZOLE-2-THIOL is utilized for its chemical properties to develop new materials with specific characteristics, such as improved stability or reactivity, for various industrial applications.

InChI:InChI=1/C8H5F3N2S/c9-8(10,11)4-1-2-5-6(3-4)13-7(14)12-5/h1-3H,(H2,12,13,14)

Upstream product

• 140-89-6 potassium ethyl xanthogenate 
• 368-71-8 4-(trifluoromethyl)-1,2-phenylenediamine 
• 400-98-6 4-trifluoromethyl-2-nitroaniline 

Downstream Products

• 106746-79-6 2-?[[(5-(Trifluoromethyl)-1H-benzimidazol-2-yl)thio]methyl]benzenamine 
• 326-55-6 5-Trifluoromethylbenzimidazole 
• 86604-69-5 5-trifluoromethyl-2-[(4-methoxy-3-methyl-pyridin-2-ylmethyl)thio]-(1H)-benzimidazole 
• 106747-32-4 3,6-Dimethyl-2-(5-trifluoromethyl-1H-benzoimidazole-2-sulfinylmethyl)-phenylamine 
• 106747-33-5 2-Methoxy-6-(5-trifluoromethyl-1H-benzoimidazole-2-sulfinylmethyl)-phenylamine 
• 106746-95-6 3,6-Dimethyl-2-(5-trifluoromethyl-1H-benzoimidazol-2-ylsulfanylmethyl)-phenylamine 
• 112059-22-0 [2-(5-Trifluoromethyl-1H-benzoimidazol-2-ylsulfanylmethyl)-phenyl]-carbamic acid benzyl ester 

Relevant academic research and scientific papers

Synthesis, biological activity, QSAR and QSPR study of 2- aminobenzimidazole derivatives as potent H3-antagonists

We report the design, synthesis, QSPR and QSAR of a new class of H 3-antagonists, having a 2-aminobenzimidazole moiety connected to the 4(5) position of an imidazole ring through di- or tri-methylene chains. Eleven substituents, selected by experimental design to obtain broad and non-correlated variation in their lipophilic, electronic and steric properties, were introduced at the 5(6) position of the benzimidazole nucleus. The compounds were tested for their H3-receptor affinity, by displacement of [3H]-(R)-α-methylhistamine ([ 3H]-RAMHA) binding to rat brain membranes (pKi), for intrinsic activity, evaluating their effect on [35S]GTPγS binding to rat brain membranes, and for H3-antagonist potency, on electrically stimulated guinea-pig ileum (pKB). The pKi values of the derivatives with longer chain (5a-k) ranged over 2 orders of magnitude, with the 5(6)-methoxy derivative 5d endowed with sub-nanomolar affinity (pKi=9.37). The series having two methylene groups in the chain spacer (4a-k), showing a small variation in affinity, revealed to be somewhat insensitive to ring substitution. Lipophilicity (log P) and basicity (pKa) of the newly synthesized compounds were measured and related to receptor affinity in a QSAR study. Multiple regression analysis (MRA) showed an approximate parabolic dependence of pKi on log P, while an additional electronic effect of the substituents on benzimidazole tautomerism is suspected.

METHOD OF USING (H+/K+)ATPASE INHIBITORS AS ANTIVIRAL AGENTS

A class of compounds which are (H+/K+) ATPase inhibitors can be used for the treatment of viral infections. Compounds of particular interest are defined by Formula III: wherein D is N or CH; wherein R7 is one or more radicals selected from hydrido, alkoxy, amino, cyano, nitro, hydroxyl, alkyl, halo, haloalkyl, carboxyl, alkanoyl, nitro, amino, alkylamino, aminocarbonyl , aminosulfonyl , alkylaminocarbonyl, alkylcarbonylamino, alkoxycarbonyl, alkylaminosulfonyl, alkylsulfonylamino, alkylthio, alkyl-sulfinyl and alkylsulfonyl; wherein R8 is selected from hydrido, alkyl and cycloalkyl; wherein R9 is one or more radicals selected from hydrido, alkoxy, amino, alkyl, halo, cyano, nitro, hydroxyl, haloalkyl, nitro, carboxyl, alkanoyl, amino, alkylamino, dialkylamino, aminocarbonyl , alkylaminocarbonyl, alkylcarbonylamino, aminosulfonyl, alkylaminosulfonyl, alkylsulfonylamino, alkoxycarbonyl, alkylthio, alkylsulfinyl and alkylsulfonyl; and wherein R10 and R11 are independently selected from hydrido, alkyl, aryl, alkylcarbonyl and arylcarbonyl wherein the aryl ring may be further substituted with one or more radicals selected from alkyl, halo, hydrazidylcarbonyl, aminocarbonyl and alkoxy; or wherein R10 and R11 together with the nitrogen atom form a heterocyclic ring

2-[(Imidazo[1,2-a]pyridinylmethyl)sulfinyl]-1H-benzimidazoles

This invention relates to 2-[(imidazo[1,2-a]pyridinylmethyl)-sulfinyl]-1H-benzimidazoles that are useful in the treatment and prevention of ulcers.

2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects

4- or 5-Trifluoromethyl-2-[(4-methoxy-2-pyridylmethyl)thio or sulfinyl]-(-benzimidazoles are useful as such or in medicament compositions for protecting the stomach and intestines and for inhibiting gastric acid secretion of warm-blooded animals to which they are administered.