N-((5-(((5-cyano-4'-fluoro-[1,1'-biphenyl]-2-yl)oxy)methyl)-4,5 dihydroisoxazol-3-yl)methyl)imidazo[1,2-a]pyridine-6-carboxamide

Base Information

Chemical Name:N-((5-(((5-cyano-4'-fluoro-[1,1'-biphenyl]-2-yl)oxy)methyl)-4,5 dihydroisoxazol-3-yl)methyl)imidazo[1,2-a]pyridine-6-carboxamide
CAS No.:1620291-49-7
Molecular Formula:C₂₆H₂₀FN₅O₃
Molecular Weight:469.475
Hs Code.:

Synonyms:N-((5-(((5-cyano-4'-fluoro-[1,1'-biphenyl]-2-yl)oxy)methyl)-4,5 dihydroisoxazol-3-yl)methyl)imidazo[1,2-a]pyridine-6-carboxamide

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Chemical Property of N-((5-(((5-cyano-4'-fluoro-[1,1'-biphenyl]-2-yl)oxy)methyl)-4,5 dihydroisoxazol-3-yl)methyl)imidazo[1,2-a]pyridine-6-carboxamide

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Technology Process of N-((5-(((5-cyano-4'-fluoro-[1,1'-biphenyl]-2-yl)oxy)methyl)-4,5 dihydroisoxazol-3-yl)methyl)imidazo[1,2-a]pyridine-6-carboxamide

There total 6 articles about N-((5-(((5-cyano-4'-fluoro-[1,1'-biphenyl]-2-yl)oxy)methyl)-4,5 dihydroisoxazol-3-yl)methyl)imidazo[1,2-a]pyridine-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1620293-70-0
N-((5-((2-bromo-4-cyanophenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)imidazo[1,2-a]pyridine-6-carboxamide

: 1765-93-1
4-fluoroboronic acid

: 1620291-49-7
N-((5-(((5-cyano-4'-fluoro-[1,1'-biphenyl]-2-yl)oxy)methyl)-4,5 dihydroisoxazol-3-yl)methyl)imidazo[1,2-a]pyridine-6-carboxamide

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In 1,4-dioxane; water; at 90 ℃; for 16h; Inert atmosphere;

Reference yield:

: 2315-86-8
3-bromo-4-hydroxybenzonitrile

: 1620291-49-7
N-((5-(((5-cyano-4'-fluoro-[1,1'-biphenyl]-2-yl)oxy)methyl)-4,5 dihydroisoxazol-3-yl)methyl)imidazo[1,2-a]pyridine-6-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate; potassium iodide / acetone / 2 h / Reflux

2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 20 °C

2.2: 36 h / 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 12 h / 0 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 20 °C

5.1: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 16 h / 90 °C / Inert atmosphere

With hydrogenchloride; N-chloro-succinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; potassium iodide; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetone; 5.1: |Suzuki Coupling;

Reference yield:

: 2973-78-6
3-bromo-4-hydroxybenzylaldehyde

: 1620291-49-7
N-((5-(((5-cyano-4'-fluoro-[1,1'-biphenyl]-2-yl)oxy)methyl)-4,5 dihydroisoxazol-3-yl)methyl)imidazo[1,2-a]pyridine-6-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydroxylamine hydrochloride / dimethyl sulfoxide / 2 h / 90 °C

2.1: potassium carbonate; potassium iodide / acetone / 2 h / Reflux

3.1: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 20 °C

3.2: 36 h / 20 °C

4.1: hydrogenchloride / 1,4-dioxane / 12 h / 0 - 20 °C

5.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 20 °C

6.1: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 16 h / 90 °C / Inert atmosphere

With hydrogenchloride; N-chloro-succinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; hydroxylamine hydrochloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; potassium iodide; In 1,4-dioxane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; 6.1: |Suzuki Coupling;