3-((4-(4-amino-3-(trifluoromethoxy)benzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide

Base Information

• Chemical Name: 3-((4-(4-amino-3-(trifluoromethoxy)benzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide
• CAS No.: 1124213-88-2
• Molecular Formula: C₂₄H₂₉F₃N₄O₃
• Molecular Weight: 478.514
• Mol file: 1124213-88-2.mol

Synonyms:3-((4-(4-amino-3-(trifluoromethoxy)benzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide

Chemical Property of 3-((4-(4-amino-3-(trifluoromethoxy)benzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-((4-(4-amino-3-(trifluoromethoxy)benzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide

There total 4 articles about 3-((4-(4-amino-3-(trifluoromethoxy)benzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-amino-3-(trifluoromethoxy)benzoic acid (175278-22-5) + N-tert-butyl-3-(piperazin-1-ylmethyl)benzamide (1124212-41-4) → 3-((4-(4-amino-3-(trifluoromethoxy)benzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide (1124213-88-2)

Guidance literature:

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

N-tert-butyl-3-(chloromethyl)benzamide (1094362-66-9) → 3-((4-(4-amino-3-(trifluoromethoxy)benzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide (1124213-88-2)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 20 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 2.5 h / 60 °C

3: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine / dichloromethane / 20 °C

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide;

Reference yield:

3-(Chloromethyl)benzoyl chloride (63024-77-1) → 3-((4-(4-amino-3-(trifluoromethoxy)benzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide (1124213-88-2)

Guidance literature:

Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / -30 - 20 °C

2: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 20 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 2.5 h / 60 °C

4: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine / dichloromethane / 20 °C

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide;

upstream raw materials:

4-amino-3-(trifluoromethoxy)benzoic acid

N-tert-butyl-3-(piperazin-1-ylmethyl)benzamide

N-tert-butyl-3-(chloromethyl)benzamide

tert-butyl 4-(3-(tert-butylcarbamoyl)benzyl)piperazine-1-carboxylate

Downstream raw materials:

N-tert-butyl-3-((4-(4-(3-isobutylureido)-3-(trifluoromethoxy)benzoyl)piperazin-1-yl)methyl)benzamide