tert-butyl 4-(3-(tert-butylcarbamoyl)benzyl)piperazine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-(3-(tert-butylcarbamoyl)benzyl)piperazine-1-carboxylate
• CAS No.: 1124211-94-4
• Molecular Formula: C₂₁H₃₃N₃O₃
• Molecular Weight: 375.511
• Mol file: 1124211-94-4.mol

Synonyms:tert-butyl 4-(3-(tert-butylcarbamoyl)benzyl)piperazine-1-carboxylate

Chemical Property of tert-butyl 4-(3-(tert-butylcarbamoyl)benzyl)piperazine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-(3-(tert-butylcarbamoyl)benzyl)piperazine-1-carboxylate

There total 2 articles about tert-butyl 4-(3-(tert-butylcarbamoyl)benzyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tert-butyl-3-(chloromethyl)benzamide (1094362-66-9) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-(3-(tert-butylcarbamoyl)benzyl)piperazine-1-carboxylate (1124211-94-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 20 ℃; Product distribution / selectivity; Inert atmosphere;

Reference yield:

3-(Chloromethyl)benzoyl chloride (63024-77-1) → tert-butyl 4-(3-(tert-butylcarbamoyl)benzyl)piperazine-1-carboxylate (1124211-94-4)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / -30 - 20 °C

2: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 20 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; In dichloromethane; dimethyl sulfoxide;

Reference yield:

tert-butyl 4-(3-(tert-butylcarbamoyl)benzyl)piperazine-1-carboxylate (1124211-94-4) → N-tert-butyl-3-(piperazin-1-ylmethyl)benzamide dihydrochloride

Guidance literature:

With hydrogenchloride; In ethanol; at 20 ℃; for 4h;

upstream raw materials:

N-tert-butyl-3-(chloromethyl)benzamide

1-t-Butoxycarbonylpiperazine

3-(Chloromethyl)benzoyl chloride

Downstream raw materials:

N-tert-butyl-3-(piperazin-1-ylmethyl)benzamide

3-((4-(4-aminobenzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide

N-tert-butyl-3-((4-(4-nitrobenzoyl)piperazin-1-yl)methyl)benzamide

3-((4-(2-aminopyrazine-5-carbonyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide