Technology Process of (S)-6-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-(1-fluoroethyl)imidazo[2,1-b][1,3,4]thiadiazole
There total 9 articles about (S)-6-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-(1-fluoroethyl)imidazo[2,1-b][1,3,4]thiadiazole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
dichloromethane; isopropyl alcohol;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: N-Bromosuccinimide; sodium hydrogencarbonate / tetrahydrofuran; ethyl acetate
2: dichloromethane; isopropyl alcohol
With
N-Bromosuccinimide; sodium hydrogencarbonate;
In
tetrahydrofuran; dichloromethane; ethyl acetate; isopropyl alcohol;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: diisobutylaluminium hydride / dichloromethane; toluene / 3.33 h / -78 °C
1.2: 0.5 h
2.1: caesium carbonate / N,N-dimethyl-formamide / 0.17 h
2.2: 18.08 h / 22 °C / Inert atmosphere
3.1: toluene-4-sulfonic acid / tetrahydrofuran; ethyl acetate / 1 h / 20 °C
4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.92 h / -78 °C / Inert atmosphere
4.2: 0.42 h / -78 °C / Inert atmosphere
5.1: sodium hydrogencarbonate; N-Bromosuccinimide / tetrahydrofuran / 2.25 h / -20 - 0 °C
6.1: isopropyl alcohol / 18 h / 80 °C
With
N-Bromosuccinimide; diisobutylaluminium hydride; sodium hydrogencarbonate; caesium carbonate; toluene-4-sulfonic acid; lithium hexamethyldisilazane;
In
tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; toluene;
