(S)-6-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-(1-fluoroethyl)imidazo[2,1-b][1,3,4]thiadiazole

Base Information

Chemical Name:(S)-6-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-(1-fluoroethyl)imidazo[2,1-b][1,3,4]thiadiazole
CAS No.:1476848-37-9
Molecular Formula:C₂₂H₁₈FN₃O₃S
Molecular Weight:423.468
Hs Code.:

Synonyms:(S)-6-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-(1-fluoroethyl)imidazo[2,1-b][1,3,4]thiadiazole

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Chemical Property of (S)-6-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-(1-fluoroethyl)imidazo[2,1-b][1,3,4]thiadiazole

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Technology Process of (S)-6-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-(1-fluoroethyl)imidazo[2,1-b][1,3,4]thiadiazole

There total 9 articles about (S)-6-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-(1-fluoroethyl)imidazo[2,1-b][1,3,4]thiadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1476847-52-5
1-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-bromoethanone

: 1476848-36-8
(S)-5-(1-fluoroethyl)-1,3,4-thiadiazol-2-amine

: 1476848-37-9
(S)-6-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-(1-fluoroethyl)imidazo[2,1-b][1,3,4]thiadiazole

Guidance literature:: In dichloromethane; isopropyl alcohol;

Reference yield:

: toluene-ethyl acetate

: 1476848-37-9
(S)-6-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-(1-fluoroethyl)imidazo[2,1-b][1,3,4]thiadiazole

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide; sodium hydrogencarbonate / tetrahydrofuran; ethyl acetate

2: dichloromethane; isopropyl alcohol

With N-Bromosuccinimide; sodium hydrogencarbonate; In tetrahydrofuran; dichloromethane; ethyl acetate; isopropyl alcohol;

Reference yield:

: 1476847-49-0
5-(benzyloxy)-7-methoxy-2,2-dimethyl-4H-benzo[d][1,3 ]dioxin-4-one

: 1476848-37-9
(S)-6-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-(1-fluoroethyl)imidazo[2,1-b][1,3,4]thiadiazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: diisobutylaluminium hydride / dichloromethane; toluene / 3.33 h / -78 °C

1.2: 0.5 h

2.1: caesium carbonate / N,N-dimethyl-formamide / 0.17 h

2.2: 18.08 h / 22 °C / Inert atmosphere

3.1: toluene-4-sulfonic acid / tetrahydrofuran; ethyl acetate / 1 h / 20 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.92 h / -78 °C / Inert atmosphere

4.2: 0.42 h / -78 °C / Inert atmosphere

5.1: sodium hydrogencarbonate; N-Bromosuccinimide / tetrahydrofuran / 2.25 h / -20 - 0 °C

6.1: isopropyl alcohol / 18 h / 80 °C

With N-Bromosuccinimide; diisobutylaluminium hydride; sodium hydrogencarbonate; caesium carbonate; toluene-4-sulfonic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; toluene;