(4Z,2R)-4-(2-benzyloxymethoxyethyl)-2-triethylsilyloxy-6-triisopropylsilyloxyhex-4-en-1-ol

Base Information

Chemical Name:(4Z,2R)-4-(2-benzyloxymethoxyethyl)-2-triethylsilyloxy-6-triisopropylsilyloxyhex-4-en-1-ol
CAS No.:1083349-13-6
Molecular Formula:C₃₁H₅₈O₅Si₂
Molecular Weight:566.97
Hs Code.:

Synonyms:(4Z,2R)-4-(2-benzyloxymethoxyethyl)-2-triethylsilyloxy-6-triisopropylsilyloxyhex-4-en-1-ol

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Chemical Property of (4Z,2R)-4-(2-benzyloxymethoxyethyl)-2-triethylsilyloxy-6-triisopropylsilyloxyhex-4-en-1-ol

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Technology Process of (4Z,2R)-4-(2-benzyloxymethoxyethyl)-2-triethylsilyloxy-6-triisopropylsilyloxyhex-4-en-1-ol

There total 8 articles about (4Z,2R)-4-(2-benzyloxymethoxyethyl)-2-triethylsilyloxy-6-triisopropylsilyloxyhex-4-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1083349-11-4
(4Z,2R)-4-(2-benzyloxymethoxyethyl)-1-(4-methoxybenzyloxy)-2-triethylsilyloxy-6-tri-isopropylsilyloxyhex-4-ene

: 1083349-13-6
(4Z,2R)-4-(2-benzyloxymethoxyethyl)-2-triethylsilyloxy-6-triisopropylsilyloxyhex-4-en-1-ol

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; at 0 - 20 ℃; for 3h; pH=7; aq. phosphate buffer;
DOI:10.1016/j.tetlet.2008.08.075

Reference yield:

: 807363-99-1
methyl (2Z,5R)-5-hydroxy-6-(4-methoxybenzyloxy)-3-prop-2-enylhex-2-enoate

: 1083349-13-6
(4Z,2R)-4-(2-benzyloxymethoxyethyl)-2-triethylsilyloxy-6-triisopropylsilyloxyhex-4-en-1-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1H-imidazole / dichloromethane / 2 h / 20 °C

2.1: 4-methylmorpholine N-oxide; osmium(VIII) oxide / water; acetone; tert-butyl alcohol / 4 h / 20 °C

3.1: sodium periodate / methanol; tetrahydrofuran / 0 °C

3.2: 1 h / Cooling

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 20 °C

5.1: diisobutylaluminium hydride / methanol; n-heptane; toluene / -78 - 0 °C

5.2: 1 h / 20 °C

6.1: 1H-imidazole / dichloromethane / 20 °C

7.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; aq. phosphate buffer / 0 - 10 °C / pH 7

With 1H-imidazole; sodium periodate; osmium(VIII) oxide; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; methanol; aq. phosphate buffer; n-heptane; dichloromethane; water; acetone; toluene; tert-butyl alcohol;
DOI:10.1039/c7ob02127e

Reference yield:

: 1083349-08-9
methyl (2Z,5R)-3-(2-hydroxyethyl)-6-(4-methoxybenzyloxy)-5-triethylsilyloxyhex-2-enoate

: 1083349-13-6
(4Z,2R)-4-(2-benzyloxymethoxyethyl)-2-triethylsilyloxy-6-triisopropylsilyloxyhex-4-en-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 20 °C

2.1: diisobutylaluminium hydride / methanol; n-heptane; toluene / -78 - 0 °C

2.2: 1 h / 20 °C

3.1: 1H-imidazole / dichloromethane / 20 °C

4.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; aq. phosphate buffer / 0 - 10 °C / pH 7

With 1H-imidazole; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; methanol; aq. phosphate buffer; n-heptane; dichloromethane; toluene;
DOI:10.1039/c7ob02127e