2-[(4-hydroxy-phenyl)-(2-oxo-2-phenyl-ethyl)-amino]-1-phenyl-ethanone

Base Information

• Chemical Name: 2-[(4-hydroxy-phenyl)-(2-oxo-2-phenyl-ethyl)-amino]-1-phenyl-ethanone
• CAS No.: 1000775-43-8
• Molecular Formula: C₂₂H₁₉NO₃
• Molecular Weight: 345.398
• Mol file: 1000775-43-8.mol

Synonyms:2-[(4-hydroxy-phenyl)-(2-oxo-2-phenyl-ethyl)-amino]-1-phenyl-ethanone

Chemical Property of 2-[(4-hydroxy-phenyl)-(2-oxo-2-phenyl-ethyl)-amino]-1-phenyl-ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-[(4-hydroxy-phenyl)-(2-oxo-2-phenyl-ethyl)-amino]-1-phenyl-ethanone

There total 1 articles about 2-[(4-hydroxy-phenyl)-(2-oxo-2-phenyl-ethyl)-amino]-1-phenyl-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-amino-phenol (123-30-8) + α-bromoacetophenone (70-11-1) → 2-[(4-hydroxy-phenyl)-(2-oxo-2-phenyl-ethyl)-amino]-1-phenyl-ethanone (1000775-43-8)

Guidance literature:

With sodium carbonate; In ethanol; for 4h; Heating;

DOI:10.1021/jo050236r

Reference yield:

2-[(4-hydroxy-phenyl)-(2-oxo-2-phenyl-ethyl)-amino]-1-phenyl-ethanone (1000775-43-8) → 4-(3,4-diphenyl-2,5-dihydro-pyrrol-1-yl)-phenol (859157-96-3)

Guidance literature:

With titanium tetrachloride; zinc; In tetrahydrofuran; at 20 ℃; for 24h;

DOI:10.1021/jo050236r

Reference yield:

2-[(4-hydroxy-phenyl)-(2-oxo-2-phenyl-ethyl)-amino]-1-phenyl-ethanone (1000775-43-8) → 4-(3,4-diphenyl-pyrrol-1-yl)-phenol

Guidance literature:

Multi-step reaction with 2 steps

1: TiCl₄; Zn / tetrahydrofuran / 24 h / 20 °C

2: 82 percent / CH₂Cl₂ / UV-irradiation

With titanium tetrachloride; zinc; In tetrahydrofuran; dichloromethane; 1: McMurry coupling;

DOI:10.1021/jo050236r

upstream raw materials:

4-amino-phenol

α-bromoacetophenone

Downstream raw materials:

4-(3,4-diphenyl-2,5-dihydro-pyrrol-1-yl)-phenol