(4-chloro-phenyl)-{2-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamino]-thiazol-5-yl}-methanol

Base Information

Chemical Name:(4-chloro-phenyl)-{2-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamino]-thiazol-5-yl}-methanol
CAS No.:1077629-61-8
Molecular Formula:C₂₁H₁₉ClN₄O₂S
Molecular Weight:426.926
Hs Code.:

Synonyms:(4-chloro-phenyl)-{2-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamino]-thiazol-5-yl}-methanol

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Chemical Property of (4-chloro-phenyl)-{2-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamino]-thiazol-5-yl}-methanol

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Technology Process of (4-chloro-phenyl)-{2-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamino]-thiazol-5-yl}-methanol

There total 7 articles about (4-chloro-phenyl)-{2-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamino]-thiazol-5-yl}-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1077629-62-9
(5-formyl-thiazol-2-yl)-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-carbamic acid tert-butyl ester

: 873-77-8
(4-chlorphenyl)magnesium bromide

: 1077629-61-8
(4-chloro-phenyl)-{2-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamino]-thiazol-5-yl}-methanol

Guidance literature:: (5-formyl-thiazol-2-yl)-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-carbamic acid tert-butyl ester; (4-chlorphenyl)magnesium bromide; In tetrahydrofuran; diethyl ether; at -78 - 0 ℃; for 1.5h;

With water; ammonium chloride; In tetrahydrofuran; diethyl ether;

Reference yield:

: 1077629-28-7
2-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamino]-thiazole-5-carbaldehyde

: 873-77-8
(4-chlorphenyl)magnesium bromide

: 1077629-61-8
(4-chloro-phenyl)-{2-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamino]-thiazol-5-yl}-methanol

Guidance literature:: 2-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamino]-thiazole-5-carbaldehyde; With dmap; di-tert-butyl dicarbonate; In dichloromethane; at 0 - 20 ℃; for 12h;

(4-chlorphenyl)magnesium bromide; In tetrahydrofuran; at -78 - 0 ℃; for 0.5h;
DOI:10.1016/j.bmcl.2011.08.060

Reference yield:

: 1077629-28-7
2-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamino]-thiazole-5-carbaldehyde

: 1077629-61-8
(4-chloro-phenyl)-{2-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamino]-thiazol-5-yl}-methanol

Guidance literature:: Multi-step reaction with 2 steps

1: dmap / dichloromethane / 0 - 20 °C

2: tetrahydrofuran; diethyl ether / 1.5 h / -78 - 0 °C

dmap; In tetrahydrofuran; diethyl ether; dichloromethane;