1,3,2',6'-tetra-N-(benzyloxycarbonyl)-2,3-O-cyclohexylideneribostamycin

Base Information

• Chemical Name: 1,3,2',6'-tetra-N-(benzyloxycarbonyl)-2,3-O-cyclohexylideneribostamycin
• CAS No.: 63064-74-4
• Molecular Formula: C₅₅H₆₆N₄O₁₈
• Molecular Weight: 1071.15
• Mol file: 63064-74-4.mol

Synonyms:1,3,2',6'-tetra-N-(benzyloxycarbonyl)-2,3-O-cyclohexylideneribostamycin

Chemical Property of 1,3,2',6'-tetra-N-(benzyloxycarbonyl)-2,3-O-cyclohexylideneribostamycin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3,2',6'-tetra-N-(benzyloxycarbonyl)-2,3-O-cyclohexylideneribostamycin

There total 1 articles about 1,3,2',6'-tetra-N-(benzyloxycarbonyl)-2,3-O-cyclohexylideneribostamycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

cycloxexanone dimethyl ketal (933-40-4) + 1,3,2',6'-tetra-N-(benzyloxycarbonyl)ribostamycin (37077-05-7,51040-83-6) → 1,3,2',6'-tetra-N-(benzyloxycarbonyl)-2,3-O-cyclohexylideneribostamycin (63064-74-4)

Guidance literature:

With toluene-4-sulfonic acid; In N,N-dimethyl-formamide; at 70 ℃; for 20h;

DOI:10.1246/bcsj.53.3259

Reference yield: 98.0%

acetic anhydride (108-24-7) + 1,3,2',6'-tetra-N-(benzyloxycarbonyl)-2,3-O-cyclohexylideneribostamycin (63064-74-4) → 6,3',4',5-tetra-O-acetyl-1,3,2',6'-tetra-N-(benzyloxycarbonyl)-2,3-O-cyclohexylideneribostamycin (63064-75-5)

Guidance literature:

In pyridine; Ambient temperature;

DOI:10.1246/bcsj.53.3259

Reference yield:

1,3,2',6'-tetra-N-(benzyloxycarbonyl)-2,3-O-cyclohexylideneribostamycin (63064-74-4) → 6,3',4',5-tetra-O-acetyl-1,3,2',6'-tetra-N-(benzyloxycarbonyl)ribostamycin (63064-76-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / pyridine / Ambient temperature

2: 35 percent / 50percent aq. acetic acid / 12 h / 80 °C

With acetic acid; In pyridine;

DOI:10.1246/bcsj.53.3259

upstream raw materials:

cycloxexanone dimethyl ketal

1,3,2',6'-tetra-N-(benzyloxycarbonyl)ribostamycin

Downstream raw materials:

6,3',4',5-tetra-O-acetyl-1,3,2',6'-tetra-N-(benzyloxycarbonyl)-2,3-O-cyclohexylideneribostamycin

6,3',4',5-tetra-O-acetyl-1,3,2',6'-tetra-N-(benzyloxycarbonyl)ribostamycin

Refernces