N-[3-(naphthalen-1-ylamino)propanoyl]phenylalanine methyl ester

Base Information

• Chemical Name: N-[3-(naphthalen-1-ylamino)propanoyl]phenylalanine methyl ester
• CAS No.: 938069-34-2
• Molecular Formula: C₂₃H₂₄N₂O₃
• Molecular Weight: 376.455
• Mol file: 938069-34-2.mol

Synonyms:N-[3-(naphthalen-1-ylamino)propanoyl]phenylalanine methyl ester

Chemical Property of N-[3-(naphthalen-1-ylamino)propanoyl]phenylalanine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[3-(naphthalen-1-ylamino)propanoyl]phenylalanine methyl ester

There total 4 articles about N-[3-(naphthalen-1-ylamino)propanoyl]phenylalanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methyl (2S)-2-amino-3-phenylpropanoate (2577-90-4) + 3-(naphthalen-1-ylamino)propanoic acid (6580-22-9) → N-[3-(naphthalen-1-ylamino)propanoyl]phenylalanine methyl ester (938069-34-2)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.tetlet.2007.03.070

Reference yield: 85.0%

3-(naphthalen-1-ylamino)propanoic acid (6580-22-9) + methyl (2S)-2-amino-3-phenylpropanoate hydrochloride (7524-50-7) → N-[3-(naphthalen-1-ylamino)propanoyl]phenylalanine methyl ester (938069-34-2)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.tet.2007.09.042

Reference yield:

methyl 3-(naphthalen-1-ylamino)propanoate (6580-20-7) → N-[3-(naphthalen-1-ylamino)propanoyl]phenylalanine methyl ester (938069-34-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / NaOH / dioxane

2: 85 percent / DCC; HOBt / dimethylformamide / 20 °C

With sodium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2007.03.070

upstream raw materials:

methyl (2S)-2-amino-3-phenylpropanoate

3-(naphthalen-1-ylamino)propanoic acid

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

methyl 3-(naphthalen-1-ylamino)propanoate