5-(1-(3,4-dimethoxybenzoyl)indolin-4-yl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one

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Chemical Name:5-(1-(3,4-dimethoxybenzoyl)indolin-4-yl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one
CAS No.:1622172-99-9
Molecular Formula:C₃₃H₃₃N₅O₆
Molecular Weight:595.655
Hs Code.:

Synonyms:5-(1-(3,4-dimethoxybenzoyl)indolin-4-yl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one

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Chemical Property of 5-(1-(3,4-dimethoxybenzoyl)indolin-4-yl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one

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Technology Process of 5-(1-(3,4-dimethoxybenzoyl)indolin-4-yl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one

There total 7 articles about 5-(1-(3,4-dimethoxybenzoyl)indolin-4-yl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

: 1622173-54-9
5-(indolin-4-yl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one

: 93-07-2
Veratric acid

: 1622172-99-9
5-(1-(3,4-dimethoxybenzoyl)indolin-4-yl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h;

Reference yield:

: 1622173-53-8
5-(1H-indol-4-yl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one

: 1622172-99-9
5-(1-(3,4-dimethoxybenzoyl)indolin-4-yl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium cyanoborohydride; trifluoroacetic acid / 1.33 h / 0 - 20 °C / Inert atmosphere

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

With sodium cyanoborohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In N,N-dimethyl-formamide;

Reference yield:

: 5397-76-2
1-morpholin-4-yl-1-(4-nitro-phenyl)-methanone

: 1622172-99-9
5-(1-(3,4-dimethoxybenzoyl)indolin-4-yl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C

2: dimethyl amine / 16 h / 110 °C

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,4-dioxane / 2 h / 100 °C / Sealed tube; Inert atmosphere

4: sodium cyanoborohydride; trifluoroacetic acid / 1.33 h / 0 - 20 °C / Inert atmosphere

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; hydrogen; sodium cyanoborohydride; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; methanol; dimethyl amine; N,N-dimethyl-formamide;