MORPHOLINO(4-NITROPHENYL)METHANONE

Base Information

• Chemical Name: MORPHOLINO(4-NITROPHENYL)METHANONE
• CAS No.: 5397-76-2
• Molecular Formula: C11H12 N2 O4
• Molecular Weight: 236.227
• Hs Code.: 2934999090
• Mol file: 5397-76-2.mol

Synonyms:Morpholine,4-(4-nitrobenzoyl)- (9CI); Morpholine, 4-(p-nitrobenzoyl)- (8CI);(Morpholin-4-yl)(4-nitrophenyl)methanone; 4-(4-Nitrobenzoyl)morpholine;4-(p-Nitrobenzoyl)morpholine; N-(4-Nitrobenzoyl)morpholine;N-(p-Nitrobenzoyl)morpholine; NSC 4261

Chemical Property of MORPHOLINO(4-NITROPHENYL)METHANONE

Chemical Property:

• Vapor Pressure: 4.59E-08mmHg at 25°C
• Melting Point: 100-103°C
• Boiling Point: 443.6°C at 760 mmHg
• Flash Point: 222.1°C
• PSA: 75.36000
• Density: 1.331g/cm³
• LogP: 1.52830

Purity/Quality:

99%, ^*data from raw suppliers

Morpholino(4-nitrophenyl)methanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of MORPHOLINO(4-NITROPHENYL)METHANONE

There total 39 articles about MORPHOLINO(4-NITROPHENYL)METHANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

morpholine (110-91-8,99108-56-2) + 4-nitro-benzoyl chloride (122-04-3) → 1-morpholin-4-yl-1-(4-nitro-phenyl)-methanone (5397-76-2)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 60 ℃; Cooling with ice;

Reference yield: 100.0%

morpholine (110-91-8,99108-56-2) + 4-nitro-benzoic acid (62-23-7) → 1-morpholin-4-yl-1-(4-nitro-phenyl)-methanone (5397-76-2)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.bmcl.2018.03.045

Reference yield: 98.0%

morpholine (110-91-8,99108-56-2) + 4-nitrobenzaldehdye (555-16-8) → 1-morpholin-4-yl-1-(4-nitro-phenyl)-methanone (5397-76-2)

Guidance literature:

With tert.-butylhydroperoxide; In acetonitrile; at 80 ℃; for 5h;

DOI:10.1021/ol7014626

upstream raw materials:

tert-Butyl thionitrate

4-(p-nitrothiobenzoyl)morpholine

morpholine

p-nitrobenzoyl fluoride

Downstream raw materials:

(4-nitrophenyl)(1H-pyrrole-2-yl)methanone

(4-amino-phenyl)-morpholin-4-yl-methanone

(4-((6-(1-(4-(tert-butyl)benzoyl)-1H-indol-4-yl)imidazo[1,2-a]pyrazin-8-yl)amino)phenyl)(morpholino)methanone

5-(1-acetylindolin-5-yl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one

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