tert-butyl (3S,4R)-3-({cyclopropyl[3-(2-methoxyethoxy)-5-(3-methoxypropyl)benzyl]amino}carbonyl)-4-(3,4-difluorophenyl)-4-hydroxypiperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl (3S,4R)-3-({cyclopropyl[3-(2-methoxyethoxy)-5-(3-methoxypropyl)benzyl]amino}carbonyl)-4-(3,4-difluorophenyl)-4-hydroxypiperidine-1-carboxylate
• CAS No.: 1160186-11-7
• Molecular Formula: C₃₄H₄₆F₂N₂O₇
• Molecular Weight: 632.745

Synonyms:tert-butyl (3S,4R)-3-({cyclopropyl[3-(2-methoxyethoxy)-5-(3-methoxypropyl)benzyl]amino}carbonyl)-4-(3,4-difluorophenyl)-4-hydroxypiperidine-1-carboxylate

Chemical Property of tert-butyl (3S,4R)-3-({cyclopropyl[3-(2-methoxyethoxy)-5-(3-methoxypropyl)benzyl]amino}carbonyl)-4-(3,4-difluorophenyl)-4-hydroxypiperidine-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl (3S,4R)-3-({cyclopropyl[3-(2-methoxyethoxy)-5-(3-methoxypropyl)benzyl]amino}carbonyl)-4-(3,4-difluorophenyl)-4-hydroxypiperidine-1-carboxylate

There total 1 articles about tert-butyl (3S,4R)-3-({cyclopropyl[3-(2-methoxyethoxy)-5-(3-methoxypropyl)benzyl]amino}carbonyl)-4-(3,4-difluorophenyl)-4-hydroxypiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + (3S,4R)-N-cyclopropyl-4-(3,4-difluorophenyl)-4-hydroxy-N-[3-(2-methoxyethoxy)-5-(3-methoxypropyl)benzyl]piperidine-3-carboxamide (1160185-86-3) → tert-butyl (3S,4R)-3-({cyclopropyl[3-(2-methoxyethoxy)-5-(3-methoxypropyl)benzyl]amino}carbonyl)-4-(3,4-difluorophenyl)-4-hydroxypiperidine-1-carboxylate (1160186-11-7)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 14h;

Reference yield:

tert-butyl (3S,4R)-3-({cyclopropyl[3-(2-methoxyethoxy)-5-(3-methoxypropyl)benzyl]amino}carbonyl)-4-(3,4-difluorophenyl)-4-hydroxypiperidine-1-carboxylate (1160186-11-7) + 2-Bromoethyl methyl ether (6482-24-2) → tert-butyl (3S,4R)-3-({cyclopropyl[3-(2-methoxyethoxy)-5-(3-methoxypropyl)benzyl]amino}carbonyl)-4-(3,4-difluorophenyl)-4-(2-methoxyethoxy)piperidine-1-carboxylate (1160186-18-4)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 80 ℃; for 0.5h;

Reference yield:

tert-butyl (3S,4R)-3-({cyclopropyl[3-(2-methoxyethoxy)-5-(3-methoxypropyl)benzyl]amino}carbonyl)-4-(3,4-difluorophenyl)-4-hydroxypiperidine-1-carboxylate (1160186-11-7) + methyl iodide (74-88-4) → rac-tert-butyl (3S,4R)-3-({cyclopropyl[3-(2-methoxyethoxy)-5-(3-methoxypropyl)benzyl]amino}carbonyl)-4-(3,4-difluorophenyl)-4-methoxypiperidine-1-carboxylate (1160186-12-8)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 80 - 90 ℃;

upstream raw materials:

di-tert-butyl dicarbonate

(3S,4R)-N-cyclopropyl-4-(3,4-difluorophenyl)-4-hydroxy-N-[3-(2-methoxyethoxy)-5-(3-methoxypropyl)benzyl]piperidine-3-carboxamide

Downstream raw materials:

tert-butyl (3S,4R)-3-({cyclopropyl[3-(2-methoxyethoxy)-5-(3-methoxypropyl)benzyl]amino}carbonyl)-4-(3,4-difluorophenyl)-4-(2-methoxyethoxy)piperidine-1-carboxylate

rac-tert-butyl (3S,4R)-3-({cyclopropyl[3-(2-methoxyethoxy)-5-(3-methoxypropyl)benzyl]amino}carbonyl)-4-(3,4-difluorophenyl)-4-methoxypiperidine-1-carboxylate

tert-butyl (3S,4R)-3-({cyclopropyl[3-(2-methoxyethoxy)-5-(3-methoxypropyl)benzyl]amino}carbonyl)-4-(3,4-difluorophenyl)-4-(prop-2-yn-1-yloxy)piperidine-1-carboxylate

tert-butyl (3S,4R)-4-(allyloxy)-3-({cyclopropyl[3-(2-methoxyethoxy)-5-(3-methoxypropyl)benzyl]amino}carbonyl)-4-(3,4-difluorophenyl)piperidine-1-carboxylate

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