(3S)-5-Oxo-3-phenyl-D-proline ethyl ester

Base Information

Chemical Name:(3S)-5-Oxo-3-phenyl-D-proline ethyl ester
CAS No.:246231-99-2
Molecular Formula:C₁₃H₁₅NO₃
Molecular Weight:233.267
Hs Code.:
DSSTox Substance ID:DTXSID101269220
Nikkaji Number:J274.890H

Synonyms:DTXSID101269220;(3S)-5-Oxo-3-phenyl-D-proline ethyl ester;(2R)-5-Oxo-3alpha-phenylpyrrolidine-2beta-carboxylic acid ethyl ester;246231-99-2

Suppliers and Price of (3S)-5-Oxo-3-phenyl-D-proline ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S)-5-Oxo-3-phenyl-D-proline ethyl ester

Chemical Property:

XLogP3:1.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:233.10519334
Heavy Atom Count:17
Complexity:297

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C1C(CC(=O)N1)C2=CC=CC=C2
Isomeric SMILES:CCOC(=O)[C@H]1[C@@H](CC(=O)N1)C2=CC=CC=C2

Technology Process of (3S)-5-Oxo-3-phenyl-D-proline ethyl ester

There total 7 articles about (3S)-5-Oxo-3-phenyl-D-proline ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 246231-99-2
ethyl (2R,3S)-3-phenylpyroglutamate

Guidance literature:: With pyridine N-oxide; In tetrahydrofuran; at 20 ℃; for 96h;
DOI:10.1021/jo9819739

Reference yield: 29.0%

: 246231-98-1
ethyl 5-[(1R,2S,5R)-8-phenylmenthyl](2R,3S)-2-amino-3-phenylglutarate

: 246231-99-2
ethyl (2R,3S)-3-phenylpyroglutamate

Guidance literature:: With hydroxylamine hydrochloride; sodium acetate; In ethanol; for 72h; Heating;
DOI:10.1021/jo9819739

Reference yield:

: 1-ethyl 5-[(1R,2S,5R)-8-phenylmenthyl](3S)-2-(N,N-dibenzylamino)-3-phenylglutarate

: 246231-99-2
ethyl (2R,3S)-3-phenylpyroglutamate

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 5 percent Pd/C / ethanol / 15 h / 50 °C / 2068.59 Torr

2: 29 percent / NH₂OH*HCl; NaOAc / ethanol / 72 h / Heating

With hydroxylamine hydrochloride; hydrogen; sodium acetate; palladium on activated charcoal; In ethanol; 1: Catalytic hydrogenation / 2: Reduction;
DOI:10.1021/jo9819739