cyclo<2,2-dimethyl-β-alanyl-(2S)-2-hydroxy-4-(methylpentanoyl)-(2E,5S,6S)-5-hydroxy-6-<(2R,3R)-3-phenyloxiranyl>-2-heptenoyl-4-amino-3-chloro-D-phenylalanyl>

Base Information

Chemical Name:cyclo<2,2-dimethyl-β-alanyl-(2S)-2-hydroxy-4-(methylpentanoyl)-(2E,5S,6S)-5-hydroxy-6-<(2R,3R)-3-phenyloxiranyl>-2-heptenoyl-4-amino-3-chloro-D-phenylalanyl>
CAS No.:240428-96-0
Molecular Formula:C₃₅H₄₄ClN₃O₇
Molecular Weight:654.203
Hs Code.:

cyclo<2,2-dimethyl-β-alanyl-(2S)-2-hydroxy-4-(methylpentanoyl)-(2E,5S,6S)-5-hydroxy-6-<(2R,3R)-3-phenyloxiranyl>-2-heptenoyl-4-amino-3-chloro-D-phenylalanyl>

Synonyms:cyclo<2,2-dimethyl-β-alanyl-(2S)-2-hydroxy-4-(methylpentanoyl)-(2E,5S,6S)-5-hydroxy-6-<(2R,3R)-3-phenyloxiranyl>-2-heptenoyl-4-amino-3-chloro-D-phenylalanyl>

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Chemical Property of cyclo<2,2-dimethyl-β-alanyl-(2S)-2-hydroxy-4-(methylpentanoyl)-(2E,5S,6S)-5-hydroxy-6-<(2R,3R)-3-phenyloxiranyl>-2-heptenoyl-4-amino-3-chloro-D-phenylalanyl>

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Technology Process of cyclo<2,2-dimethyl-β-alanyl-(2S)-2-hydroxy-4-(methylpentanoyl)-(2E,5S,6S)-5-hydroxy-6-<(2R,3R)-3-phenyloxiranyl>-2-heptenoyl-4-amino-3-chloro-D-phenylalanyl>

There total 2 articles about cyclo<2,2-dimethyl-β-alanyl-(2S)-2-hydroxy-4-(methylpentanoyl)-(2E,5S,6S)-5-hydroxy-6-<(2R,3R)-3-phenyloxiranyl>-2-heptenoyl-4-amino-3-chloro-D-phenylalanyl> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: (2-Chloro-4-{(E)-(3S,10R,16S)-3-isobutyl-6,6-dimethyl-2,5,9,12-tetraoxo-16-[(S)-1-(3-phenyl-oxiranyl)-ethyl]-1,4-dioxa-8,11-diaza-cyclohexadec-13-en-10-ylmethyl}-phenyl)-carbamic acid 9H-fluoren-9-ylmethyl ester

: 240428-96-0
cyclo<2,2-dimethyl-β-alanyl-(2S)-2-hydroxy-4-(methylpentanoyl)-(2E,5S,6S)-5-hydroxy-6-<(2R,3R)-3-phenyloxiranyl>-2-heptenoyl-4-amino-3-chloro-D-phenylalanyl>

: (E)-(3S,10R,16S)-10-(4-Amino-3-chloro-benzyl)-3-isobutyl-6,6-dimethyl-16-[(S)-1-((2S,3S)-3-phenyl-oxiranyl)-ethyl]-1,4-dioxa-8,11-diaza-cyclohexadec-13-ene-2,5,9,12-tetraone

Guidance literature:: With piperidine; In N,N-dimethyl-formamide; for 6h; Ambient temperature;
DOI:10.1021/jm980706s

Reference yield:

: 240428-80-2
cyclo<2,2-dimethyl-β-alanyl-(2S)-2-hydroxy-4-(methylpentanoyl)-(2E,5S,6R,7E)-5-hydroxy-6-methyl-8-phenyl-2,7-octadienoyl-3-chloro-4-<<(9H-fluoren-9-ylmethoxy)carbonyl>amino>-D-phenylalanyl>

: 240428-96-0
cyclo<2,2-dimethyl-β-alanyl-(2S)-2-hydroxy-4-(methylpentanoyl)-(2E,5S,6S)-5-hydroxy-6-<(2R,3R)-3-phenyloxiranyl>-2-heptenoyl-4-amino-3-chloro-D-phenylalanyl>

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 25 °C

2: 32 percent / piperidine / dimethylformamide / 6 h / Ambient temperature

With piperidine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm980706s