(2S,3R)-benzyl 4-hydroxy-3-methyl-2-(9-phenyl-9H-fluoren-9-ylamino)butanoate

Base Information

Chemical Name:(2S,3R)-benzyl 4-hydroxy-3-methyl-2-(9-phenyl-9H-fluoren-9-ylamino)butanoate
CAS No.:482632-10-0
Molecular Formula:C₃₁H₂₉NO₃
Molecular Weight:463.576
Hs Code.:

Synonyms:(2S,3R)-benzyl 4-hydroxy-3-methyl-2-(9-phenyl-9H-fluoren-9-ylamino)butanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3R)-benzyl 4-hydroxy-3-methyl-2-(9-phenyl-9H-fluoren-9-ylamino)butanoate

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Technology Process of (2S,3R)-benzyl 4-hydroxy-3-methyl-2-(9-phenyl-9H-fluoren-9-ylamino)butanoate

There total 5 articles about (2S,3R)-benzyl 4-hydroxy-3-methyl-2-(9-phenyl-9H-fluoren-9-ylamino)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 482631-94-7
(2S)-1-benzyl 4-methyl 3-methyl-2-(9-phenyl-9H-fluoren-9-ylamino)succinate

: 482631-95-8
(2S,3S)-benzyl 4-hydroxy-3-methyl-2-(9-phenyl-9H-fluoren-9-ylamino)butanoate

: 482632-10-0
(2S,3R)-benzyl 4-hydroxy-3-methyl-2-(9-phenyl-9H-fluoren-9-ylamino)butanoate

Guidance literature:: With diisobutylaluminum hydride; In hexane; dichloromethane; at -78 ℃;
DOI:10.1016/S0968-0896(02)00206-7

Reference yield:

: 1-benzyl 4-methyl (2S,3S)-3-methyl-2-(9-phenyl-9H-fluoren-9-ylamino)succinate

: 1-benzyl 4-methyl (2S,3R)-3-methyl-2-(9-phenyl-9H-fluoren-9-ylamino)succinate

: 482631-95-8
(2S,3S)-benzyl 4-hydroxy-3-methyl-2-(9-phenyl-9H-fluoren-9-ylamino)butanoate

: 482632-10-0
(2S,3R)-benzyl 4-hydroxy-3-methyl-2-(9-phenyl-9H-fluoren-9-ylamino)butanoate

Guidance literature:: 1-benzyl 4-methyl (2S,3S)-3-methyl-2-(9-phenyl-9H-fluoren-9-ylamino)succinate; 1-benzyl 4-methyl (2S,3R)-3-methyl-2-(9-phenyl-9H-fluoren-9-ylamino)succinate; With diisobutylaluminium hydride; In tetrahydrofuran; hexane; at -78 ℃; for 20.1667h;

With phosphoric acid; water; In tetrahydrofuran; hexane;

Reference yield:

: 7362-93-8
(S)-3-amino-4-(benzyloxy)-4-oxobutanoic acid

: 482631-95-8
(2S,3S)-benzyl 4-hydroxy-3-methyl-2-(9-phenyl-9H-fluoren-9-ylamino)butanoate

: 482632-10-0
(2S,3R)-benzyl 4-hydroxy-3-methyl-2-(9-phenyl-9H-fluoren-9-ylamino)butanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / 29.25 h / 20 °C / Cooling with ice/water

2.1: triethylamine; lead(II) nitrate / dichloromethane / 48 h / 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.17 h / -78 °C

3.2: 16.63 h / -78 - 20 °C

4.1: diisobutylaluminium hydride / hexane; tetrahydrofuran / 20.16 h / -78 °C

With thionyl chloride; lead(II) nitrate; diisobutylaluminium hydride; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; dichloromethane;