(2S)-1-benzyl 4-methyl 3-methyl-2-(9-phenyl-9H-fluoren-9-ylamino)succinate

Base Information

• Chemical Name: (2S)-1-benzyl 4-methyl 3-methyl-2-(9-phenyl-9H-fluoren-9-ylamino)succinate
• CAS No.: 482631-94-7
• Molecular Formula: C₃₂H₂₉NO₄
• Molecular Weight: 491.587
• Mol file: 482631-94-7.mol

Synonyms:(2S)-1-benzyl 4-methyl 3-methyl-2-(9-phenyl-9H-fluoren-9-ylamino)succinate

Chemical Property of (2S)-1-benzyl 4-methyl 3-methyl-2-(9-phenyl-9H-fluoren-9-ylamino)succinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-1-benzyl 4-methyl 3-methyl-2-(9-phenyl-9H-fluoren-9-ylamino)succinate

There total 4 articles about (2S)-1-benzyl 4-methyl 3-methyl-2-(9-phenyl-9H-fluoren-9-ylamino)succinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-1-benzyl 4-methyl 2-(9-phenyl-9H-fluoren-9-ylamino)succinate (1007880-96-7) + methyl iodide (74-88-4) → (2S)-1-benzyl 4-methyl 3-methyl-2-(9-phenyl-9H-fluoren-9-ylamino)succinate (482631-94-7)

Guidance literature:

(S)-1-benzyl 4-methyl 2-(9-phenyl-9H-fluoren-9-ylamino)succinate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

methyl iodide; In tetrahydrofuran; for 16.5h;

Reference yield:

(S)-1-benzyl 4-methyl 2-aminosuccinate (51298-61-4) → (2S)-1-benzyl 4-methyl 3-methyl-2-(9-phenyl-9H-fluoren-9-ylamino)succinate (482631-94-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine; lead(II) nitrate / dichloromethane / 48 h / 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.17 h / -78 °C

2.2: 16.63 h / -78 - 20 °C

With lead(II) nitrate; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;

Reference yield:

(S)-3-amino-4-(benzyloxy)-4-oxobutanoic acid (7362-93-8) → (2S)-1-benzyl 4-methyl 3-methyl-2-(9-phenyl-9H-fluoren-9-ylamino)succinate (482631-94-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: thionyl chloride / 29.25 h / 20 °C / Cooling with ice/water

2.1: triethylamine; lead(II) nitrate / dichloromethane / 48 h / 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.17 h / -78 °C

3.2: 16.63 h / -78 - 20 °C

With thionyl chloride; lead(II) nitrate; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;

upstream raw materials:

(S)-1-benzyl 4-methyl 2-(9-phenyl-9H-fluoren-9-ylamino)succinate

methyl iodide

(S)-3-amino-4-(benzyloxy)-4-oxobutanoic acid

(S)-1-benzyl 4-methyl 2-aminosuccinate

Downstream raw materials:

(2S,3R)-benzyl 4-(tert-butyldimethylsilyloxy)-3-methyl-2-(9-phenyl-9H-fluoren-9-ylamino)butanoate

(3S,4R)-4-methyl-3-(9-phenyl-9H-fluoren-9-ylamino)dihydrofuran-2(3H)-one

(2S,3S)-benzyl 4-hydroxy-3-methyl-2-(9-phenyl-9H-fluoren-9-ylamino)butanoate

(2S,3R)-2-Methyl-3-(9-phenyl-9H-fluoren-9-ylamino)-succinic acid 4-benzyl ester