(6-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-1-methoxymethyl-5-pyridin-4-yl-1H-imidazol-4-yl}-isoquinolin-1-yl)-bis-(4-methoxy-benzyl)-amine

Base Information

Chemical Name:(6-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-1-methoxymethyl-5-pyridin-4-yl-1H-imidazol-4-yl}-isoquinolin-1-yl)-bis-(4-methoxy-benzyl)-amine
CAS No.:1426083-07-9
Molecular Formula:C₄₅H₄₆N₆O₄
Molecular Weight:734.898
Hs Code.:

Synonyms:(6-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-1-methoxymethyl-5-pyridin-4-yl-1H-imidazol-4-yl}-isoquinolin-1-yl)-bis-(4-methoxy-benzyl)-amine

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Chemical Property of (6-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-1-methoxymethyl-5-pyridin-4-yl-1H-imidazol-4-yl}-isoquinolin-1-yl)-bis-(4-methoxy-benzyl)-amine

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Technology Process of (6-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-1-methoxymethyl-5-pyridin-4-yl-1H-imidazol-4-yl}-isoquinolin-1-yl)-bis-(4-methoxy-benzyl)-amine

There total 4 articles about (6-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-1-methoxymethyl-5-pyridin-4-yl-1H-imidazol-4-yl}-isoquinolin-1-yl)-bis-(4-methoxy-benzyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 1251931-22-2
{2-[4-(4-bromo-1-methoxymethyl-5-pyridin-4-yl-1H-imidazol-2-yl)-phenoxy]-ethyl}-dimethyl-amine

: 1426082-94-1
bis-(4-methoxy-benzyl)-[6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-isoquinolin-1-yl]-amine

: 1426083-07-9
(6-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-1-methoxymethyl-5-pyridin-4-yl-1H-imidazol-4-yl}-isoquinolin-1-yl)-bis-(4-methoxy-benzyl)-amine

Guidance literature:: With palladium diacetate; potassium carbonate; triphenylphosphine; In 1,2-dimethoxyethane; water; for 2h; Reflux;
DOI:10.1016/j.bmc.2012.12.035

Reference yield:

: 1426082-50-9
(6-bromo-isoquinolin-1-yl)-bis-(4-methoxy-benzyl)-amine

: 1426083-07-9
(6-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-1-methoxymethyl-5-pyridin-4-yl-1H-imidazol-4-yl}-isoquinolin-1-yl)-bis-(4-methoxy-benzyl)-amine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 90 °C

2: potassium carbonate; triphenylphosphine; palladium diacetate / water; 1,2-dimethoxyethane / 2 h / Reflux

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; palladium diacetate; potassium carbonate; triphenylphosphine; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; 2: |Suzuki Coupling;
DOI:10.1016/j.bmc.2012.12.035

Reference yield:

: 215453-26-2
(6-bromoisoquinolin-1-yl)amine

: 1426083-07-9
(6-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-1-methoxymethyl-5-pyridin-4-yl-1H-imidazol-4-yl}-isoquinolin-1-yl)-bis-(4-methoxy-benzyl)-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h

1.2: 1.5 h / 20 °C

2.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 90 °C

3.1: potassium carbonate; triphenylphosphine; palladium diacetate / water; 1,2-dimethoxyethane / 2 h / Reflux

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; palladium diacetate; sodium hydride; potassium carbonate; triphenylphosphine; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; mineral oil; 3.1: |Suzuki Coupling;
DOI:10.1016/j.bmc.2012.12.035