bis-(4-methoxy-benzyl)-[6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-isoquinolin-1-yl]-amine

Base Information

Chemical Name:bis-(4-methoxy-benzyl)-[6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-isoquinolin-1-yl]-amine
CAS No.:1426082-94-1
Molecular Formula:C₃₁H₃₅BN₂O₄
Molecular Weight:510.441
Hs Code.:

Synonyms:bis-(4-methoxy-benzyl)-[6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-isoquinolin-1-yl]-amine

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Chemical Property of bis-(4-methoxy-benzyl)-[6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-isoquinolin-1-yl]-amine

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Technology Process of bis-(4-methoxy-benzyl)-[6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-isoquinolin-1-yl]-amine

There total 3 articles about bis-(4-methoxy-benzyl)-[6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-isoquinolin-1-yl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1426082-50-9
(6-bromo-isoquinolin-1-yl)-bis-(4-methoxy-benzyl)-amine

: 73183-34-3
bis(pinacol)diborane

: 1426082-94-1
bis-(4-methoxy-benzyl)-[6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-isoquinolin-1-yl]-amine

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In N,N-dimethyl-formamide; at 90 ℃;
DOI:10.1016/j.bmc.2012.12.035

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 1426082-94-1
bis-(4-methoxy-benzyl)-[6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-isoquinolin-1-yl]-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h

1.2: 1.5 h / 20 °C

2.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 90 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; sodium hydride; In N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2012.12.035

Reference yield:

: 215453-26-2
(6-bromoisoquinolin-1-yl)amine

: 1426082-94-1
bis-(4-methoxy-benzyl)-[6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-isoquinolin-1-yl]-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h

1.2: 1.5 h / 20 °C

2.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 90 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; sodium hydride; In N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2012.12.035