E-ethyl α-benzilydene-1,2,3,4-tetrahydro-7-methoxy-2-methyl-1,3-dioxo-4-isoquinolineacetate

Base Information

• Chemical Name: E-ethyl α-benzilydene-1,2,3,4-tetrahydro-7-methoxy-2-methyl-1,3-dioxo-4-isoquinolineacetate
• CAS No.: 82083-49-6
• Molecular Formula: C₂₂H₂₁NO₅
• Molecular Weight: 379.412
• Mol file: 82083-49-6.mol

Synonyms:E-ethyl α-benzilydene-1,2,3,4-tetrahydro-7-methoxy-2-methyl-1,3-dioxo-4-isoquinolineacetate

Chemical Property of E-ethyl α-benzilydene-1,2,3,4-tetrahydro-7-methoxy-2-methyl-1,3-dioxo-4-isoquinolineacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of E-ethyl α-benzilydene-1,2,3,4-tetrahydro-7-methoxy-2-methyl-1,3-dioxo-4-isoquinolineacetate

There total 1 articles about E-ethyl α-benzilydene-1,2,3,4-tetrahydro-7-methoxy-2-methyl-1,3-dioxo-4-isoquinolineacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

ethyl 2-diethylphosphono-3-phenylpropionate (142570-65-8,35085-32-6) + 7-methoxy-2-methyl-1,3,4 (2H)-isoquinolinetrione (74826-28-1) → E-ethyl α-benzilydene-1,2,3,4-tetrahydro-7-methoxy-2-methyl-1,3-dioxo-4-isoquinolineacetate (82083-49-6)

Guidance literature:

With sodium hydride; In benzene; 1.) -50 deg C; 2.) to 60 deg C;

DOI:10.1016/0040-4020(81)85028-4

Reference yield: 63.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + E-ethyl α-benzilydene-1,2,3,4-tetrahydro-7-methoxy-2-methyl-1,3-dioxo-4-isoquinolineacetate (82083-49-6) → E-ethyl α-benzylidene-1,2-dihydro-3,7-dimethoxy-2-methyl-1-oxo-4-isoquinolineacetate (82083-53-2)

Guidance literature:

In diethyl ether;

DOI:10.1016/0040-4020(81)85028-4

Reference yield:

E-ethyl α-benzilydene-1,2,3,4-tetrahydro-7-methoxy-2-methyl-1,3-dioxo-4-isoquinolineacetate (82083-49-6) → (E)-2-[4-Methoxy-2-(methoxycarbonyl-methyl-aminocarbonyl)-benzoyl]-3-phenyl-acrylic acid ethyl ester (82083-60-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / diethyl ether

2: 54 percent / cyclohexane / Irradiation

In diethyl ether; cyclohexane;

DOI:10.1016/0040-4020(81)85028-4

upstream raw materials:

ethyl 2-diethylphosphono-3-phenylpropionate

7-methoxy-2-methyl-1,3,4 (2H)-isoquinolinetrione

Downstream raw materials:

E-ethyl α-benzylidene-1,2-dihydro-3,7-dimethoxy-2-methyl-1-oxo-4-isoquinolineacetate

(E)-2-[4-Methoxy-2-(methoxycarbonyl-methyl-aminocarbonyl)-benzoyl]-3-phenyl-acrylic acid ethyl ester