ethyl 2-diethylphosphono-3-phenylpropionate

Base Information

• Chemical Name: ethyl 2-diethylphosphono-3-phenylpropionate
• CAS No.: 142570-65-8
• Molecular Formula: C₁₅H₂₃O₅P
• Molecular Weight: 314.318
• Mol file: 142570-65-8.mol

Synonyms:

Chemical Property of ethyl 2-diethylphosphono-3-phenylpropionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-diethylphosphono-3-phenylpropionate

There total 13 articles about ethyl 2-diethylphosphono-3-phenylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

chloro-trimethyl-silane (75-77-4) + (E)-3-phenyl-2-(diethoxyphosphoryl)acrylic acid ethyl ester (53235-77-1) → ethyl 2-diethylphosphono-3-phenylpropionate (142570-65-8,35085-32-6) + 2-(diethoxy-phosphoryl)-3-phenyl-3-trimethylsilanyl-propionic acid ethyl ester

Guidance literature:

With magnesium; In N,N-dimethyl-formamide; at 15 - 20 ℃; for 9h;

DOI:10.1246/cl.2002.228

Reference yield: 78.0%

diethoxyphosphoryl-acetic acid ethyl ester (867-13-0) + benzyl chloride (100-44-7) → ethyl 2-diethylphosphono-3-phenylpropionate (142570-65-8,35085-32-6)

Guidance literature:

With potassium carbonate; sodium iodide; at 60 ℃; for 96h;

DOI:10.1055/s-1986-31824

Reference yield: 78.0%

diethoxyphosphoryl-acetic acid ethyl ester (867-13-0) + benzyl bromide (100-39-0) → ethyl 2-diethylphosphono-3-phenylpropionate (142570-65-8,35085-32-6)

Guidance literature:

With potassium carbonate;

upstream raw materials:

diethoxyphosphoryl-acetic acid ethyl ester

benzyl chloride

(E)-3-phenyl-2-(diethoxyphosphoryl)acrylic acid ethyl ester

benzyl bromide

Downstream raw materials:

3-phenyl-2-phosphono-propionic acid

1-amino-2-phenylethanephosphonic acid

(1-Carbamoyl-2-phenyl-ethyl)-phosphonic acid diethyl ester

2-Benzylacrylic acid ethyl ester

Refernces

• 1、 te Grotenhuis, Colet,van den Heuvel, Naudin,van der Vlugt, Jarl Ivar,de Bruin, Bas. "Catalytic Dibenzocyclooctene Synthesis via Cobalt(III)–Carbene Radical and ortho-Quinodimethane Intermediates". supporting information. p. 140 - 145. Retrieved 2017/12/13.
• 2、 Pieroni, Marco,Annunziato, Giannamaria,Azzali, Elisa,Dessanti, Paola,Mercurio, Ciro,Meroni, Giuseppe,Trifiró, Paolo,Vianello, Paola,Villa, Manuela,Beato, Claudia,Varasi, Mario,Costantino, Gabriele. "Further insights into the SAR of α-substituted cyclopropylamine derivatives as inhibitors of histone demethylase KDM1A". . p. 377 - 386. Retrieved 2015/03/05.