TO-bis NTA

Base Information

• Chemical Name: TO-bis NTA
• CAS No.: 862778-50-5
• Molecular Formula: C₅₇H₉₅N₅O₁₆
• Molecular Weight: 1106.41
• Mol file: 862778-50-5.mol

Synonyms:TO-bis NTA

Chemical Property of TO-bis NTA

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of TO-bis NTA

There total 4 articles about TO-bis NTA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-benzyloxycarbonyl-L-glutamic acid (1155-62-0) + Nα,Nα-bis[(tert-butyloxycarbonyl)methyl]-L-lysine tert-butyl ester (205379-08-4) → TO-bis NTA (862778-50-5)

Guidance literature:

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/ja050690c

Reference yield:

bromoacetic acid tert-butyl ester (5292-43-3) → TO-bis NTA (862778-50-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / EDIAP / dimethylformamide / 55 °C

2: 94 percent / H₂ / Pd/C / methanol / 6 h / 20 °C

3: 90 percent / TBTU; EDIAP / CH₂Cl₂ / 20 °C

With hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/chem.200500154

Reference yield:

Nε-benzyloxycarbonyl-L-lysine tert-butyl ester (63628-63-7) → TO-bis NTA (862778-50-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / EDIAP / dimethylformamide / 55 °C

2: 94 percent / H₂ / Pd/C / methanol / 6 h / 20 °C

3: 90 percent / TBTU; EDIAP / CH₂Cl₂ / 20 °C

With hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/chem.200500154

upstream raw materials:

N-benzyloxycarbonyl-L-glutamic acid

N^α,N^α-bis[(tert-butyloxycarbonyl)methyl]-L-lysine tert-butyl ester

bromoacetic acid tert-butyl ester

Nε-benzyloxycarbonyl-L-lysine tert-butyl ester