ethyl 10-fluoro-6-(3-fluoro-4-methoxybenzyl)-1,2,4,7-tetrahydro-3H-indolo[2,3-c][1,7]naphthyridine-3-carboxylate

Base Information

Chemical Name:ethyl 10-fluoro-6-(3-fluoro-4-methoxybenzyl)-1,2,4,7-tetrahydro-3H-indolo[2,3-c][1,7]naphthyridine-3-carboxylate
CAS No.:1207516-28-6
Molecular Formula:C₂₅H₂₃F₂N₃O₃
Molecular Weight:451.473
Hs Code.:

Synonyms:ethyl 10-fluoro-6-(3-fluoro-4-methoxybenzyl)-1,2,4,7-tetrahydro-3H-indolo[2,3-c][1,7]naphthyridine-3-carboxylate

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Chemical Property of ethyl 10-fluoro-6-(3-fluoro-4-methoxybenzyl)-1,2,4,7-tetrahydro-3H-indolo[2,3-c][1,7]naphthyridine-3-carboxylate

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Technology Process of ethyl 10-fluoro-6-(3-fluoro-4-methoxybenzyl)-1,2,4,7-tetrahydro-3H-indolo[2,3-c][1,7]naphthyridine-3-carboxylate

There total 1 articles about ethyl 10-fluoro-6-(3-fluoro-4-methoxybenzyl)-1,2,4,7-tetrahydro-3H-indolo[2,3-c][1,7]naphthyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1207516-48-0
ethyl 4-(5-fluoro-1H-indol-3-yl)-3-oxo-piperidine-1-carboxylate

: 452-14-2
2-(4-fluoro-3-methoxyphenyl)acetic acid

: 1207516-28-6
ethyl 10-fluoro-6-(3-fluoro-4-methoxybenzyl)-1,2,4,7-tetrahydro-3H-indolo[2,3-c][1,7]naphthyridine-3-carboxylate

Guidance literature:: ethyl 4-(5-fluoro-1H-indol-3-yl)-3-oxo-piperidine-1-carboxylate; With zinc(II) chloride; In diethyl ether; 1,2-dichloro-ethane; at 0 ℃; for 0.333333h; Inert atmosphere; Ice bath;

2-(4-fluoro-3-methoxyphenyl)acetic acid; With trifluoroacetic anhydride; In diethyl ether; 1,2-dichloro-ethane; at 0 - 25 ℃; for 3.41667h; Inert atmosphere;

With ammonium acetate; ammonia; In methanol; diethyl ether; 1,2-dichloro-ethane; for 18h; Reflux; Inert atmosphere;